Pat Mayo's 2025 Week 15 Fantasy Football Rankings, Starts, Sits, Sleepers, Injury Report, Player Notes

Dec 10, 2025

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FANTASY FOOTBALL WEEK 15 RANKINGS

Pat Mayo, Jake Ciely & Ian Hartitz break down everything you need to set your best lineup and win your matchup. From player rankings to sleeper calls, we’ve got you covered.

Week 15 RB Injuries

Nick Chubb (ribs) — Leaning OUT
De’Von Achane (ribs) — Questionable
Keaton Mitchell (knee) — Questionable
Alvin Kamara (Knee) — Questionable
Emari Demercado (Foot) — Questionable
Breece Hall (knee) — Questionable
Trey Benson (knee) — OUT FOR SEASON
Jerome Ford (shoulder) — Placed on IR

Week 15 RB Rankings

Devin Singletary (vs. WAS) — Each of the past four lead backs and seven of the past eight have scored over their PPR season average when facing the Commanders. Devin Singletary is fresh off of the bye and in Week 13, he turned 15 touches into 102 yards and a TD against the Patriots. Tracy is expected to play, but if injuries limit him, Singletary should be in the 12-16 touch range.

TreVeyon Henderson (vs. BUF) — Among qualified RBs, Henderson ranks eighth in PPR points per touch. Only the Giants, but rush EPA, have a worse run defense than the Bills this season.

Rams RB Machine (vs DET) — 41 RBs have 100 carries and two have picked up 5+ yards on over 43% of them ... Kyren Williams (44.9%) and Blake Corum (44.6%).

Ashton Jeanty (at PHI) — 102.4% of his rushing yards over the past month have come after contact. The Eagles, even with their recent struggles, rank 12th in rush yards allowed per carry after contact to RBs.

Tony Pollard (at SF) — He scored 21.7 fantasy points on his two long TD runs last week in CLE. He totaled 19 PPR points in the three weeks prior. The 49ers have allowed just 8 rushing TDs this season, fourth fewest.

Week 15 Spread Picks

Mayo, Geoff Fienberg and Tim Anderson go game-by-game and make their 2025 Week 15 Spread Picks, Bets, Survivor Picks, and chat about Philip Rivers returning to the NFL, Mayo’s Trip to KC, and CUst’s awful Sunday with the Jets losing to Miami and ND missing the college playoff. Plus, a mini Cust Corner on the Tip Jars, Summer vs Winter Drinks, and Half Time shows.

Week 15 WR Injuries

Drake London (Knee) — OUT
Rome Odunze (Foot) — Expected OUT
Garrett Wilson (knee) — Leaning OUT
Tee Higgins (concussion) — Leaning OUT
Mike Evans (collarbone) — Leaning IN
Jalen McMillan (neck) — Leaning IN
DK Metcalf (stomach) — Expeceted IN
CeeDee Lamb (concussion) — Questionable
Marvin Harrison Jr. (heel) — Questionable
Greg Dortch (chest) — Questionable
Dont’e Thornton (concussion) — Questionable
Parker Washington (hip) — Questionable
Kalif Raymond (ankle) — Questionable

Week 15 WR Rankings

Jakobi Meyers (vs. NYJ) — The Jets rank 28th in pressure rate this season. Smalle samples, but since joining the Jags, Meyers has a 30.4% target share when Trevor Lawrence is not pressured, 7.7% when he is pressured.

Davante Adams (vs DET) — He leads the league with 26 end zone targets, one more than George Pickens and CeeDee Lamb have… COMBINED.

Justin Jefferson struggles (at DAL) — 42 WRs have 40+ catches this season and two are averaging under 1.5 PPR points per targets: Jefferson (1.44) and Malik Washington (1.42).

2026 ONE AND DONE CONTEST

As a heads up, the Race for the Mayo Cup 2026 is OPEN FOR BUSINESS!!!!!! It starts in January per usual, but there’s now $1.2M guaranteed in the prize pool. The top 750 get paid, and just look at this glorious, flat payout structure. Everyone inside the Top 20 will win at least $10,000 with $110,000 to the winner.

The Sentry has been cancelled this year, so there won’t be a tournament to remind you to sign up for the following week. So, just reserve your spot right now as not to forget.

Tambo and I always mention how we get our dad’s entries for Christmas (since buying for a Dad is basically impossible), I highly recomend that move.

JOIN THE MAYO CUP ONE & DONE CONTEST

Week 15 TE Injuries

Cade Otton (Knee) — Expected OUT
David Njoku (knee) — Expected OUT
Darnell Washington (concussion) — Leaning OUT
Michael Mayer (Ankle) — Questionable
Brock Wright (neck) — Questionable
TJ Hockenson (shin) — Questionable
Zach Ertz (Knee) — OUT FOR SEASON

Week 15 TE Rankings

Kyle Pitts (at TB) — Only two TEs have consecutive games with 6+ catches and 80+ receiving yards this season: Trey McBride (Weeks 10-11) and Kyle Pitts (current). Opponents have completed 75.8% of their TE targets vs TB this season (sixth highest).

Week 15 QB Injuries

Jayden Daniels (Elbow) — OUT; Mariota Starting
Geno Smith (Shoulder) — Expected OUT
Tyrod Taylor (Groin) — Expected OUT
Daniel Jones (Achilles) — OUT FOR SEASON

Week 15 QB Rankings

Shedeur Sanders (at CHI) — Sanders had 149 yards on balls thrown 10+ yards last week vs TEN, the most by a Browns rookie since Baker Mayfield (Week 17, 2018). The Bears allow the third most yards per pass attempts that travel 10+ yards (12.1, NFL average: 10.1).

Marcus Mariota (at NYG) — He’s been a top-12 QB in each of his past three starts and six of his nine TD passes this season have come when not pressured. The Giants rank 24th in pressure rate this season.

Lacking Valuable Passes — Five qualified QBs average under three red zone passes per game: Michael Penix, Jaxson Dart, Jalen Hurts, Cam Ward, and Justin Fields.

Week 15 DST Rankings

Defensive Notes — Since Week 10 for all notes ... Washington is allowing points on a league-high 61.1% of drives (no other team is at even 52%), Dallas has allowed a TD on a league-high 78.6% of red zone trips (average: 53.8%), Buffalo is creating pressure on a league-low 24.3% of opponent dropbacks (Arizona is next worst: 28.1%), the Giants are the worst run defense vs RBs in terms of both yards per carry before AND after contact, Arizona is allowing a league-high 7.1 yards per first down play, Cleveland/Houston/Atlanta are the three teams with a double digit sack rate, Detroit has an opponent aDOT of 11.6 yards, 1.9 yards higher than any other defense over that stretch.