Pat Mayo's UPDATED 2025 Week 16 Fantasy Football Rankings, Starts, Sits, Sleepers, NFL Injury Report, Player Notes

Dec 17, 2025

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2026 Fantasy Football Week 16 Rankings and NFL Injuries

Pat Mayo, Jake Ciely & Ian Hartitz take Fantasy Football playoff questions from the audience to set help set their lineups while talking through the Week 16 Rankings and how to navigate the myriad Week 16 NFL Injuries to give you the best chance to win your Fantasy Championship

Week 16 RB Injuries

Bhayshul Tuten (Finger) — OUT
Alvin Kamara (Knee) — OUT
Josh Jacobs (Knee) — Questionable
Nick Chubb (ribs) — Leaning IN
Woody Marks (Ankle) — Leaning IN
RJ Harvey (ribs) — IN
Chris Rodriguez (groin) — IN
Devin Neal (hamstring) — OUT FOR SEASON
Bam Knight (knee) — OUT FOR SEASON

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Week 16 RB Injuries

Chase Brown (at MIA) — Opponents are 68-of-75 when throwing to RBs this season against MIA (90.7%, would be just the second +90% season since 2010, the 2023 Vikings also had that weakness). Two running backs have at least 4 games with 7+ catches. Christian McCaffrey (7 such games) and Chase Brown (four).

Tyler Allgeier (at ARZ) — The Cardinals are one of two teams allowing 4+ red zone trips per game (Bengals) and allow a league-high 2.6 goal-to-go trips per game. Of 43 RBs with 100+ carries, Allgeier is scoring once every 13.8 carries, the best rate in the NFL (Jahmyr Gibbs and Josh Jacobs are 2-3).

Bucky Irving (at CAR) — His 6 straight 15+ carry games is tied for the longest active streak (Javonte Williams). last season, he had 20+ rushes, 110+ rush yards and 30+ receiving yards in both games against the Panthers

Week 16 DFS Picks

Pat Mayo, Tyler Tamboline, and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 16 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, and fades for Week 16. Whether you’re entering GPPs or cash games, this guide has you covered.

Week 16 WR Injuries

Devaughn Vele (shoulder) — OUT
Rashee Rice (Concussion) — OUT
Tyquan Thornton (Concussion) — OUT
Luther Burden (ankle) — OUT
Rome Odunze (Foot) — OUT
Ricky Pearsall (knee) — Leaning OUT
Tee Higgins (Concussion) — Questionable
Pat Bryant (hamstring) — IN
Quentin Johnston (groin) — Questionable
Drake London (Knee) — Leaning IN
Hollywood Brown (personal) — IN
Christian Watson (chest) — Leaning IN
Marvin Harrison Jr. (heel) — Leaning IN
Davante Adams (Hamstring) — DNP
Garrett Wilson (knee) — OUT FOR SEASON
Noah Brown (Ribs) — OUT FOR SEASON

Week 16 WR Rankings

Jakobi Meyers — 17-game pace with JAX: 108 - 1,006 - 8.5 TDs (he’s been a top 30 PPR WR in five straight).

Jameson Williams — The only player in the NFL with 7+ catches in each of his past three games. His average TD length this season with 30 yards and only one of his seven TD receptions this season has come on an end zone target.

Wan’Dale Robinson — Six straight games with a target share over 28%, 8 games this season with a 20+ yard reception (more such games than AJ Brown, Ja’Marr Chase, and Justin Jefferson).

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Week 16 TE Injuries

Mason Taylor (Neck) — OUT
David Njoku (knee) — OUT
Noah Fant — OUT
Cade Otton (Knee) — IN
Dalton Kincaid (Knee) — IN

Week 16 TE Rankings

Colby Parkinson — T-8th in TE end zone targets this season (5). Davante Adams is likely out ... he has more end zone targets than 16 TEAMS have this year.

2026 UNDERDOG PGA BEST BALL STRATEGY & TARGETS

The 2026 Underdog PGA Best Ball lobbies are open — and if you’re drafting like it’s 2025, you’re already behind. Pat Mayo and Byron Lindeque run through the changes in rules for the new season and talk through their strategy and players to target for Underdog PGA Best Ball Drafts.

If watching or listening isn’t your thing, you can read all about it instead (or do all three!).

READ: PGA Underdog Best Ball Draft Strategy and Players to Target and Fades

Week 16 QB Injuries

Geno Smith (Shoulder) — IN
Tyrod Taylor (Groin) — Brady Cook Will Start
Tua Tagovailoa (BAD) — Quinn Ewers
Jayden Daniels (Elbow) — OUT FOR SEASON
Patrick Mahomes (Knee) — OUT FOR SEASON

Week 16 QB Rankings

Jaxson Dart (vs. MIN) — MIN is pacing to lead the NFL in blitz rate for a third straight season and they have five of the single highest blitz rate games this season. Since Week 8, Matthew Stafford leads the NFL in passer rating against the blitz (131.6). Drake Maye (122.3) and Jaxson Dart (117.1) is third. New York’s rookie is 22-of-35 for 286 yards, 3 TDs, and 0 INTs in those spots over that stretch.

Caleb Williams (vs GB) — Week 14 against the Packers: 25% complete when pressured and 69.6% when not. Remove Micah Parsons from the equation and it’s easy to see the non-pressured pass count spike.

CJ Stroud (vs. LV) — The Raiders allow the 2nd fewest yards before carry to RBs this season: HOU may control this game, but that doesn’t mean that the run game is the reason why.

Week 16 DST Rankings

The Commanders are allowing a league-high 5.5 YAC per reception to WRs this season ... a league-high 5.9% of RB carries against the Bills result in a touchdown ... The Lions have seen 133 deep passes thrown against them, 20 more than any other defense in the NFL ... The Chargers have allowed the lowest opponent passer rating this season (71.3, NFL average: 91.5) ... Since Week 10, 9% of all passes thrown against the Cardinals result in TDs, easily the highest rate in the league ... The Bengals allowed over 30 points six times last season -- they already have a league-high 7 such games this season.