Pat Mayo's 2025 Week 6 Fantasy Football Rankings, Starts, Sits, Sleepers

Oct 08, 2025

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Mayo, Jake Ciely & Ian Hartitz break down everything you need to set your best lineup and win your matchup. From player rankings to sleeper calls, we’ve got you covered.

WATCH: Fantasy Football Week 6 Rankings | Start Sit Advice, Sleepers, Busts

Week 6 RB Injuries

Tyrone Tracy (Shoulder) — IN
Jaylen Warren (Knee) — Expected IN
Antonio Gibson (Knee) — OUT FOR THE SEASON
Chuba Hubbard (Calf) — Expected OUT
Bucky Irving (Ankle) — Expected OUT
Miles Sanders (Ankle) — Questionable
Aaron Jones (Hamstring) — IR; OUT at least 1 More Week
Trey Benson (Knee) — IR; OUT at least 3 Weeks
Omarion Hampton (Ankle) —Placed on IR; OUT at least 4 Games

Week 6 RB Rankings

Qundshon Junkins — Since 2000, six RBs have opened their career with four straight games of 60 rushing yards and at least one reception: Tomlinson, Peterson, CJ2K, Dalvin Cook, Kareem Hunt, and Judkins.

Week 6 Spread Picks

Mayo, Geoff Fienberg, and Tim Anderson go game-by-game and make their 2025 Week 6 Spread Picks, Bets, Survivor Picks, and Props. Plus, a mini Cust Corner on Halloween Fun, McDonalds Monopoly Breaks, and things that are classy when you’re rich but trashy if you’re poor.

WATCH: NFL Week 6 Spread Picks, Survivor + Cust Corner

LISTEN ON APPLE

WATCH/LISTEN ON SPOTIFY

Week 6 WR Injuries

Darius Slayton (hamstring) — OUT
Allen Lazard (Personal) — OUT
Christian Watson (knee) — Practice Window Opened from IR
Jalen Coker (Quad) — Practice Window Opened from IR
CeeDee Lamb (Ankle) — Leaning OUT
Kavontae Turpin (Foot) — Questionable
Mike Evans (Hamstring) — Leaning OUT
Terry McLaurin (Quad) — Questionable
Noah Brown (Groin) — Questionable
Alec Pierce (Concussion) — Questionable
Ricky Pearsall (Knee) — Questionable
Jauan Jennings (Ankle/Shoulder) — Questionable
Cedric Tillman (Hamstring) — Placed on IR; OUT at least 4 Weeks
Brandon Aiyuk (Knee) — Practice Window Unlikely to be Opened Yet

Week 6 WR Rankings

Kayshon Boutte — The Saints create pressure at the third-lowest rate in the NFL (28% of drop-backs). Boutte has been targeted on 3.9% of routes when Drake Maye is pressured, 18.4% when not.

Jameson Williams — His aDOT is up 71.6% from last season, and that’s resulted in his catch rate crashing from 63.7% to 52.4%.

RED ZONE WATCH ALONG!!!!

After that week’s successful launch, WE’RE BACK for Week 6 Redzone. If you’re looking to hang with someone when Week 56kicks off, you can do it with me, Cust, and Friends live from MMN HQ.

We’ll be streaming RedZone and talking along over the RZ stream on Playback. Playback has the rights to RedZone, and we’ll be doing commentary while we all watch it together in perfect sync. It’ll be on YouTube as well, but we don’t have the rights to stream RedZone there, so it will just be us talking in the room.

SIGN UP FREE FOR PLAYBACK AND WATCH ALONG WITH THE PME CREW

Week 6 QB Injuries

Lamar Jackson (Hamstring) — Leaning OUT
Brock Purdy (Toe) — Leaning OUT
Joe Flacco (TRADED TO CIN) — Starting over Browning
Kyler Murray (foot) — Questionable

Week 6 QB Rankings

Matthew Stafford — Old man Stafford is one of two QBs with a 35+ yard completion in all five weeks this season (other: Sam Darnold), and it’s for a clear reason. There are six WRs with 150+ routes and a 26% (or higher) on-field target share: Puka Nacua and Davante Adams both make that list.

Aaron Rodgers — 85.1% of his passes have been thrown under 10 yards downfield (DK Metcalf has just one deep target).

Jaxson Dart — Over the past two weeks (the Dart games), the Giants rank 25th in completions to receivers and 8th in completions to running backs / tight ends (28th and 9th if you prefer the per-game rankings over that stretch).

Week 6 TE Injuries

Brock Bowers (Knee) — Leaning OUT
Michael Mayer (Concussion) — Questionable
Ja'Tavion Sanders (Ankle) — Questionable
George Kittle (Hamstring) — Questionable
Brenton Strange (Hip) — Placed on IR

Week 6 TE Rankings

Tucker Kraft — The three primary GB WRs have an aDOT of at least 14 yards, while Kraft’s sits at 5.2. In terms of opponent passer rating, the Bengals are the sixth BEST defense on passes thrown 14+ yards downfield and the third WORST on passes thrown less than 14 yards downfield.

Dalton Kincaid — This season, five players have an 18+ yard catch in all five weeks: Davante Adams, Amon-Ra St. Brown, Jaxon Smith-Njigba, Tet McMillan, and Kincaid.

Week 6 DST Rankings

BAL DST — The Ravens have allowed 19 red zone TDs (only seven other teams have allowed even 19 red zone trips) ... The Lions are allowing a league-high 4.4 deep completions per game ... The Patriots own the fourth-best defense vs RBs before contact and the fifth-best after contact.