Samuel will miss Week 13, an away game at Seattle, but the team hopes to have him back for Week 14, an early game at Cincy. The good news is owners will have time to adjust lineups if he's a game-time call in Week 14. Samuel had been seeing more work as a runner so Aiyuk and Jennings likely lead the way as receivers while Mitchell and Wilson should eat up Samuel's carries.
SF WR Brandon Aiyuk - Week 17 Fantasy Football Outlook
Week 17 vs. Houston Texans
Brandon Aiyuk found the end zone last week against the Titans, but was held to just four catches and 40 yards. Aiyuk has been quite a ride this season, but has settled into modest WR3 territory over the second half of the season, scoring the occasional touchdown, but with limited upside as the third receiving option in a Jimmy Garoppolo-led offense.
This week, Aiyuk faces a Texans defense that ranks 28th in aFPA to opposing wide receivers. However, if Jimmy Garoppolo sits and Trey Lance is the starter, it’s too risky to trust Aiyuk in the fantasy championships. If Garoppolo starts, Aiyuk is a viable WR3, but that becomes more boom-or-bust if it’s Lance behind center. Proceed with caution.