Pat Mayo's UPDATED 2025 Week 12 Fantasy Football Rankings, Starts, Sits, Sleepers, Injury Report, Player Notes

Patrick Mayo

Author twitter link

Nov 19, 2025

Pat Mayo's UPDATED 2025 Week 12 Fantasy Football Rankings, Starts, Sits, Sleepers, Injury Report, Player Notes

Albert Cesare/The Enquirer / USA TODAY NETWORK via Imagn Ima

Fantasy Football Week 12 Rankings

READ: Week 12 Weekend Cheatsheet

Week 12 RB Injuries

Bucky Irving (Foot/Shoulder) — OUT
Emari Demercado (Foot) — OUT
Trey Benson (knee) — OUT
Isiah Pacheco (knee) — OUT
Samaje Perine (ankle) — Expected OUT
Josh Jacobs (knee) — Leaning IN
Jaylen Warren (ankle) — IN
Justice Hill (toe) — IN
Bhayshul Tuten (Ankle) — IN
Rhamondre Stevenson (Toe) — IN

Week 12 RB Rankings

Jonathan Taylor — He is averaging 1.08 fantasy points per carry. The best rates for a full season during the 2000’s: 2006 Maurice Jones-Drew (1.04), 2020 Alvin Kamara (1.01), and 2006 LaDainian Tomlinson (1.00)

Ashton Jeanty (vs CLE) — The Browns allow 34% fewer yards per RB carry before contact than any other defense in the league: Jeanty ranks 38 of 42 qualified RBs in yards per carry before contact this season. Jeanty is gaining yardage on just 70% of his carries this season, the lowest rate among the 42 qualified RBs (RB average: 83%).

Week 12 Spread Picks

Mayo, Geoff Fienberg and Tim Anderson go game-by-game and make their 2025 Week 12 Spread Picks, Bets, Survivor Picks, and Props. Plus, a mini Cust Corner on the Easiest Things to do in Sports.

Week 12 WR Injuries

Ja’Marr Chase (Suspension) — OUT
Drake London (Knee) — OUT
Garrett Wilson (Knee) — OUT
Marvin Harrison (appendix) — OUT
Elic Ayomanor (hamstring) — OUT
Tory Horton (Groin/Shin) — OUT
Rashod Bateman (ankle) — OUT
Brian Thomas Jr. (ankle) — OUT
Kayshon Boutte (Hamstring) — IN
Chimere Dike (Chest) — IN
Darius Slayton (Hamstring) — IN
Chris Godwin (fibula) — Leaning IN
Calvin Ridley (ankle) — OUT FOR SEASON

Week 12 WR Rankings

Jameson Williams (vs NYG) — In the two games since Dan Campbell took over play calling duties, Jameson Williams has six catches for 108 yards and two TDs on first downs (in his first eight games this season: six catches for 123 yards and zero touchdowns in such spots).

Michael Wilson (vs JAX) — Jacoby Brissett is the giving tree when it comes to loading up his top two targets with all of the volume they can handle. He’s Joe Flacco with less press: Week 9, Marvin Harrison Jr. + Trey McBride: 65.5% of targets (19 targets) -- Week 10, Harrison + McBride: 56.8% of targets (25 targets) -- Week 11, Wilson + McBride: 51.7% of targets (29 targets).

Luther Burden III (vs PIT) — The Steelers are allowing a league-high 25.9 completions per game and 6.7 of them are picking up 15+ yards, also the most in the league. Burden is averaging 21 routes and 4 targets per game over the last two weeks (Weeks 1-9: 8.7 routes and 2.1 targets).

Tee Higgins (vs NE) — TD Regression? he’s scored on 22.7% of his Joe Flacco receptions, a rate that is more than double of his career mark otherwise (10.5%). Maybe the increased opportunity sans Chase will make it wash.

Darnell Mooney (Rest of Season) — The Falcons have an amazing schedule for boom receivers the rest of the year. Now, do you believe Mooney still has the jets to get behind a defense? If yes, do you believe Kirk Cousins can effectively hit him when he’s behind the defense? It’s. Big ask, but the opportunity for one of the ATL WRs is there for some impact fantasy games on a handful of targets if Cousins isn’t completely washed.

Week 12 TE Injuries

Tyler Higbee (Knee) — Placed on IR
Mike Gesicki (pec) — Expected IN
David Njoku (knee) — IN
Brenton Strange (hip) — Questionable
Hunter Long (hip/knee) — OUT
Austin Hooper (concussion) — Expected IN
Dalton Kincaid (hamstring) — DNP

Week 12 TE Rankings

Trey McBride — Reception leaders since the start of 2024: Ja’Marr Chase (206), McBride (182), Amon-Ra St. Brown (181), Jaxon Smith-Njigba (172).

UPSIDE — Seven times has a tight end scored 20 PPR points and five of them came from a player on a team that was favored that week.

Week 12 DraftKings Picks

Pat Mayo, Tyler Tamboline, and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 12 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 12. Whether you’re entering GPPs or cash games, this guide has you covered.

WATCH: NFL Week 12 DraftKings Picks 2025 | Best DFS NFL Lineups, Ownership Projections

“MAYO50” gets you FREE WEEK to test out Sharp Stack Do that. And if you like it, “MAYO50” unlocks 50% off the monthly sub going forward. It’s a fantatsic deal. Plus, it includes all DFS Tools, Season Long Fantasy Tools, projections and access to all sports so you can use it for CFB, NHL, and NBA.

USE CODE “MAYO50” TO GET FREE 7 DAYS OFTHE SHARP STACK BETTING TOOL 50% OFF MONTHLY PRICE

Week 12 QB Injuries

Joe Burrow — OUT; Flacco Starting
Jaxson Dart (concussion) — OUT; Jameis will start
Michael Penix (knee) — OUT; Likely for Season
Justin Fields (BAD) — Benched; Tyrod Taylor Will Start
C.J. Stroud (Concussion) — OUT
Dillon Gabriel (Concussion) — OUT; Sanders Starting
Aaron Rodgers (hand) — Leaning IN

Week 12 QB Rankings

Volume QBs — Six qualified QBs are averaging 38+ opportunities (passes + rushes) per game this season: Flacco (43.1), Mahomes (40.9), Nix (39.7), Prescott (39.5), Herbert (39.1), and Lawrence (38.7).

LOW - Daniel Jones — In Weeks 1-8, Jones averaged 0.53 fantasy points per pass and saw 5.3% of his attempts result in scores. In the two games since: 0.31 points per pass and a 2.6% TD rate.

Week 12 DST Rankings

The Titans quietly rank 3rd in sack rate since Week 4 despite ranking 25th in pressure rate over that stretch ... two defenses have yet to keep a possession out of the end zone once it got to a goal-to-goal situation and they are two of the best in the league: Patriots and Texans ... The top 5 defenses in terms of turnover rates: Bears, Rams, Jaguars, Steelers, and Colts ... Paying off the blitz. The top-5 defenses in INT% when blitzing: Bucs, Bears, Seahawks, Bills, and Chiefs.