Pat Mayo's 2025 Week 12 Fantasy Football Rankings, Starts, Sits, Sleepers, Injury Report, Player Notes

Nov 19, 2025

Albert Cesare/The Enquirer / USA TODAY NETWORK via Imagn Ima

2025 Fantasy Football Week 12 Rankings

Pat Mayo, Jake Ciely & Ian Hartitz break down everything you need to set your best lineup and win your matchup with their Fantasy Football Week 12 Rankings. From player rankings to sleeper calls, we’ve got you covered. Plus, a breakdown of the best RBs to stash on your bench the rest of the season.

Week 12 RB Injuries

Josh Jacobs (knee) — Likely OUT
Emari Demercado (Foot) — OUT
Justice Hill (toe) — Expected IN
Isiah Pacheco (knee) — Expected IN
Jaylen Warren (ankle) — Leaning IN
Trey Benson (knee) — Questionable
Bhayshul Tuten (Ankle) — Questionable
Bucky Irving (Foot/Shoulder) — Questionable
Samaje Perine (ankle) — Questionable
Rhamondre Stevenson (Toe) — Questionable

Week 12 RB Rankings

Jonathan Taylor — He is averaging 1.08 fantasy points per carry. The best rates for a full season during the 2000’s: 2006 Maurice Jones-Drew (1.04), 2020 Alvin Kamara (1.01), and 2006 LaDainian Tomlinson (1.00)

Ashton Jeanty (vs CLE) — The Browns allow 34% fewer yards per RB carry before contact than any other defense in the league: Jeanty ranks 38 of 42 qualified RBs in yards per carry before contact this season. Jeanty is gaining yardage on just 70% of his carries this season, the lowest rate among the 42 qualified RBs (RB average: 83%).

Week 12 Spread Picks

Mayo, Geoff Fienberg, and Tim Anderson go game-by-game and make their 2025 Week 12 Spread Picks, Bets, Survivor Picks, and Props. Plus, a mini Cust Corner on the Easiest Things to do in Sports.

Week 12 WR Injuries

Ja'Marr Chase (Suspension) — OUT
Drake London (Knee) — OUT
Garrett Wilson (Knee) — OUT
Marvin Harrison Jr. (appendix) — OUT
Kayshon Boutte (Hamstring) — Expected IN
Chimere Dike (Chest) — Expected IN
Elic Ayomanor (hamstring) — Questionable
Darius Slayton (Hamstring) — Questionable
Chris Godwin (fibula) — Questionable
Tory Horton (Groin/Shin) — Leaning OUT
Rashod Bateman (ankle) — Questionable
Brian Thomas Jr. (ankle) — Questionable
Calvin Ridley (ankle) — OUT FOR SEASON

Week 12 WR Rankings

Jameson Williams (vs NYG) — In the two games since Dan Campbell took over play-calling duties, Jameson Williams has six catches for 108 yards and two TDs on first downs (in his first eight games this season: six catches for 123 yards and zero touchdowns in such spots).

Michael Wilson (vs JAX) — Jacoby Brissett is the giving tree when it comes to loading up his top two targets with all of the volume they can handle. He’s Joe Flacco with less press: Week 9, Marvin Harrison Jr. + Trey McBride: 65.5% of targets (19 targets) -- Week 10, Harrison + McBride: 56.8% of targets (25 targets) -- Week 11, Wilson + McBride: 51.7% of targets (29 targets).

Luther Burden III (vs PIT) — The Steelers are allowing a league-high 25.9 completions per game, and 6.7 of them are picking up 15+ yards, also the most in the league. Burden is averaging 21 routes and 4 targets per game over the last two weeks (Weeks 1-9: 8.7 routes and 2.1 targets).

Tee Higgins (vs NE) — TD Regression? He’s scored on 22.7% of his Joe Flacco receptions, a rate that is more than double his career mark otherwise (10.5%). Maybe the increased opportunity sans Chase will make it wash.

Darnell Mooney (Rest of Season) — The Falcons have an amazing schedule for boom receivers the rest of the year. Now, do you believe Mooney still has the jets to get behind a defense? If yes, do you believe Kirk Cousins can effectively hit him when he’s behind the defense? It’s. Big ask, but the opportunity for one of the ATL WRs is there for some impact fantasy games on a handful of targets if Cousins isn’t completely washed.

Week 12 TE Injuries

Dalton Kincaid (hamstring) — Expected OUT
Tyler Higbee (Knee) — Placed on IR
Mike Gesicki (pec) — Leaning IN
David Njoku (knee) — Questionable
Brenton Strange (hip) — Questionable
Hunter Long (hip/knee) — Questionable
Austin Hooper (concussion) — Questionable

Week 12 TE Rankings

Trey McBride — Reception leaders since the start of 2024: Ja’Marr Chase (206), McBride (182), Amon-Ra St. Brown (181), Jaxon Smith-Njigba (172).

UPSIDE — Seven times a tight end has scored 20 PPR points, and five of them came from a player on a team that was favored that week.

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Week 12 QB Injuries

Joe Burrow — Leaning IN
Jaxson Dart (concussion) — Leaning IN
Michael Penix Jr. (knee) — OUT; Likely for Season
Justin Fields (BAD) — Benched; Tyrod Taylor Will Start
C.J. Stroud (Concussion) — OUT
Dillon Gabriel (Concussion) — Expected OUT; Sanders Starting
Aaron Rodgers (hand) — Questionable

Week 12 QB Rankings

Volume QBs — Six qualified QBs are averaging 38+ opportunities (passes + rushes) per game this season: Flacco (43.1), Mahomes (40.9), Nix (39.7), Prescott (39.5), Herbert (39.1), and Lawrence (38.7).

LOW - Daniel Jones — In Weeks 1-8, Jones averaged 0.53 fantasy points per pass and saw 5.3% of his attempts result in scores. In the two games since: 0.31 points per pass and a 2.6% TD rate.

Week 12 DST Rankings

The Titans quietly rank 3rd in sack rate since Week 4 despite ranking 25th in pressure rate over that stretch ... two defenses have yet to keep a possession out of the end zone once it got to a goal-to-goal situation, and they are two of the best in the league: Patriots and Texans ... The top 5 defenses in terms of turnover rates: Bears, Rams, Jaguars, Steelers, and Colts ... Paying off the blitz. The top-5 defenses in INT% when blitzing: Bucs, Bears, Seahawks, Bills, and Chiefs.