Pat Mayo's Updated Week 4 Fantasy Football Rankings and NFL Injuries

Sep 24, 2025

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FANTASY FOOTBALL WEEK 4 RANKINGS

Mayo, Jake Ciely & Ian Hartitz break down everything you need to set your best lineup and win your matchup. They debate fantasy football Weke 4 player rankings, buy lows, and sleeper calls while answering viewer add/drop and trade questions.

Week 4 RB Injuries

Tyrone Tracy (Shoulder) — OUT 2-4 Weeks
Aaron Jones (Hamstring) — IR; OUT at least 3 More Games
Will Shipley (Ribs) — IN
Jacory Croskey-Merritt (knee) — Leaning IN

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Week 4 RB Rankings

James Cook — His last 13 regular season games with more than 10 carries: 20.8 PPR PPG, 5.4 YPC, 17 rush TD. Cook has 64 red zone touches in 19 games since the beginning of last season. He had 49 in 33 games prior to that during the first 2 seasons of his career. 15+ point favorites since 2000 score an average of 31.5 PPG

Ashton Jeanty — The Bears allow a league high 2.29 YPC before contact to RB, Jeanty averages 3.11 YPC after contact. Could he average 5.4 YPC this week??

Week 4 Props & Sharp Stack Discount

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Here are the current top value props…

Week 4 WR Injuries

Davante Adams (Hamstring) — Questionable
Jauan Jennings (Ankle/Shoulder) — Questionable
CeeDee Lamb (Ankle) — OUT 2-4 Weeks
Mike Evans (Hamstring) — OUT 2-4 Weeks
Chris Godwin — Questionable
Terry McLaurin (Quad) — OUT
Alec Pierce (Concussion) — OUT
Noah Brown (Groin) — Leaning OUT
Xavier Legette (Hamstring) — OUT
Dyami Brown (shoulder) — Leaning IN
Xavier Worthy (Shoulder) — IN; Potentially Limited
Josh Reynolds (Hamstring) — IN
Jordan Addison (Suspension) — Returning From Suspension
DeMarcus Robinson (Suspension) — Returning From Suspension

Week 4 WR Rankings

Ja’Marr Chase & Tee Higgins — With Browning since 2023: Higgins (16.4 aDOT) and Chase (8.0 aDOT). Denver this season, 2nd most YPA on short passes, 4th fewest on deep passes.

Hunter Renfrow — Christian Gonzalez likely back and on Tet. NE allows a league high 9.5 YPA to the slot, Renfrow: 82.5% of routes come in slot.

Week 4 Spread Picks Cheatsheet

Pat Mayo, Geoff Fienberg and Tim Anderson go game-by-game and make their 2025 Week 4 Spread Picks, Bets, Survivor Picks while previewing every NFL Week 4 game. Plus, a mini Cust Corner on Bowling, Regifting, and earlier start times.

WATCH: NFL Week 4 Spread Picks, Survivor Picks, Ryder Cup | Cust Corner: Bowling, Regifting

Week 4 QB Injuries

Jayden Daniels (Knee) — OUT
JJ McCarthy (Ankle) — OUT 1-4 Weeks
Justin Fields (Concussion) — IN
Brock Purdy (Shoulder/Toe) — IN

Week 4 QB Rankings

Michael Penix — He completed 44.8% of deep passes last season (21st of 46 qualifiers). This season, he’s 2-of-17 (11.8%, easily dead last in the league).

Daniel Jones — More like Danny Designs ... Jones is 13/15 this season when throwing from outside of the pocket as the Colts master the bootleg play design through three weeks.

Jared Goff — 6 QBs averagd 20 FPPG last season. Goff in home wins with the Lions: 20.9 FPPG. Joe Burrow is the only pocket-locked QB over Cleveland’s past 25 games to score 19+ FP against them. Since the start of 2023, Goff has cleared 18.2 FP in a short rest game just once (six such games played).

Week 4 TE Injuries

Michael Mayer (Concussion) — OUT
Ja’Tavion Sanders (Ankle) — OUT 2-4 Weeks
Will Dissly (Knee) — OUT
George Kittle (Hamstring) — OUT Another 1-4 Weeks
Isaiah Likely (Foot) — Leaning IN
Noah Fant (Concussion) — Leaning OUT
Tyler Higbee (hip) — Leaning IN
Colston Loveland (Hip) — Questionable
Evan Engram (Back) — IN
Darren Waller (hip) — Leaning IN

Week 4 TE Rankings

Week 4 DST Rankings

GB: 2 20+ yard completions allowed (no one else is under 5) ... CIN/SEA: Only teams yet to allow a 15+ yard rush ... WAS: the league’s best 3rd down defense ... LAC: the league’s best RZ defense

WATCH FOR: The Browns DST being dropped since they play the Lions this week. No, they aren’t a great play in Detroit this week, but coming up: MIN/PIT/MIA/NE/BYE/NYJ. They’ll be ranked as a Top 10 option in all of those weeks.