Pat Mayo's UPDATED 2025 Week 10 Fantasy Football Rankings, Starts, Sits, Sleepers, Injury Report

Nov 05, 2025

Junfu Han / USA TODAY NETWORK via Imagn Images

Fantasy Football Week 10 Rankings

Pat Mayo, Jake Ciely & Ian Hartitz break down everything you need to set your best lineup and win your matchup with their Fantasy Football Week 10 Rankings. From player rankings to sleeper calls, we’ve got you covered.

Week 10 RB Injuries

Bucky Irving (Foot/Shoulder) — OUT
Rhamondre Stevenson (Toe) — OUT
Aaron Jones (Shoulder) — Questionable
D’Andre Swift (Groin) — IN
Saquon Barkley (groin) — Expected IN
Quinshon Judkins (shoulder) — IN
JK Dobbins (Foot) — Questionable

Week 10 RB Rankings

Rico Dowdle — Dowdle has at least 17 carries in four of his past five games, 23+ in three of those instances. Three times this season has a RB had 17+ carries against the Saints: they all cleared 110 rushing yards and each of them ran for a score (D’Andre Swift, James Cook, and Kyren Williams combined to carry 66 times for 355 yards, 5.6 YPC). Dowdle is suffering from a new quad injury however which could stop him from hitting his touch ceiling.

20 Carry Club — Only four RBs have at least three games with 20+ rush attempts this season: Christian McCaffrey (4), James Cook (3), Quinshon Judkins (3), and Rico Dowdle (3).

BEARS RBS — There are four RBs with 60+ carries who are averaging 2+ yards per carry before contact: James Cook, Jahmyr Gibbs, D’Andre Swift, and Kyle Monangai.

EXPLOSIVE RBs — 23 RBs have 100+ carries this season. D’Andre Swift (17%), Breece Hall (15.4%), and Kenneth Walker (15.1%) are 1-2-3 in percentage of attempts that have gained 10+ yards. Jahmyr Gibbs (8.8%), Quinshon Judkins (8.5%), and Alvin Kamara (7.5%) rank 21-22-23.

Week 10 Spread Picks

Mayo, Geoff Fienberg and Tim Anderson go game-by-game and make their 2025 Week 10 Spread Picks, Bets, and recap the NFL Trade Deadline. Plus, a mini Cust Corner on Cust’s top sauces.

Week 10 WR Injuries

Chris Godwin (fibula) — OUT
Brian Thomas Jr. (ankle) — OUT
Terry McLaurin (Quad) — OUT
Ricky Pearsall (Knee) — OUT
Kayshon Boutte (Hamstring) — OUT
Isaiah Bond — OUT
Tory Horton (Groin/Shin) — Expected OUT
Matthew Golden (shoulder) — Leaning OUT
Garrett Wilson (knee) — IN
Puka Nacua (Ribs) — IN
Cedric Tillman (hamstring) — IN
Dyami Brown (Concussion) — IN
Luther Burden III (concussion) — Expected IN
Cooper Kupp (heel, hamstring) — Leaning IN
Dontayvion Wicks (calf) — Questionable
Joshua Palmer (knee, ankle) — Questionable
Brandon Aiyuk (Knee) — Estimated Week 11-13 Return

Week 10 WR Rankings

Michael Wilson — 1.46 yards per route run with Jacoby Brissett under center this season (0.35 with Kyler Murray).

Rashid Shaheed — Sam Darnold when throwing deep (15+ air yards) ranks top 5 in ... YPA, fantasy PPG, completion percentage, passer rating, and touchdown pass rate.

Michael Pittman — Pittman is doing things differently. This season, just 17.6% of his targets have come deep downfield: among the other 14 top 15 PPR receivers, the average deep ball rate is 29.5%. That’s a valuable skill set against the Falcons defense that owns the sixth-lowest opponent deep CMP% through nine weeks.

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Week 10 TE Injuries

Cole Kmet (Concussion) — IN
Harold Fannin (Hamstring) — Questionable
Hunter Long (hip/knee) — OUT
Tucker Kraft (Knee) — OUT FOR SEASON
Josh Oliver — OUT
Daniel Bellinger (neck) — IN

Week 10 TE Rankings

Trey McBride — The average TD pass against the Seahawks has been 11.7 yards, the fifth shortest in the league. The three QBs with the shortest average distance of touchdown pass this season are Jacoby Brissett (9.3 yards), Carson Wentz (8.5), and Kyler Murray (6.7).

Week 10 QB Injuries

C.J. Stroud (Concussion) — OUT
Jayden Daniels (Elbow) — OUT Indefinitely
Brock Purdy (Toe) — Mac Jones Will Start
Kyler Murray (Foot) — PLACED ON IR

Week 10 QB Rankings

Jacoby Brissett — Only QB to log 3 straight games with 260+ pass yards and 2+ pass TDs this season. During the past month, he’s 5th in non-pressured passer rating and 20th in pressured passer rating (SEA: third in non-blitz pressure rate over that stretch).

Lamar Jackson — There are 35 QBs with 100+ passes thrown this season and Lamar Jackson ranks 14th in percentage of fantasy points scored on the ground (Jake Browning and Russell Wilson both somehow rank ahead of him!)

Week 10 DST Rankings

The Vikings lead the league in non-blitz pressure rate and they face a Ravens team that allows non-blitz pressure at the highest rate in the league ... In Weeks 1-6, the Commanders allowed 2.03 points per drive (12th fewest). Since then, their rate is up to 3.32 (third most) ... The Patriots are tough on defense, but 75% of red zone trips against them have resulted in a TD, the highest rate in the NFL ... The Bears are allowing 7.0 yards per first down play, the third most through nine weeks of a season since 2018.