2025 Week 10 NFL Weekend Cheatsheet: Injuries, Picks, DFS, Props, Updated Rankings

Nov 08, 2025

Jeff Lange / USA TODAY NETWORK via Imagn Images

WEEK 10 NFL CHEATSHEET

Mayo updates his 2025 Fantasy Football Week 10 rankings with the latest news and goes through the Week 10 NFL Injury Report telling you who is in and out and which players stand to benefit. Mayo then goes through his favorite Week 10 Props and fills out an Underdog Pick’em Entry before getting to his Top Cheap Plays on DraftKings for Week 10 at each position.

WATCH: NFL Week 10 Weekend Cheatsheet: Updated Rankings, Injuries, Player Props | DraftKings Picks Ownership, Values

WEEK 10 NFL INJURIES

Week 10 RB Injuries

Bucky Irving (Foot/Shoulder) — OUT
Rhamondre Stevenson (Toe) — OUT
Aaron Jones (Shoulder) — Questionable
D'Andre Swift (Groin) — IN
Saquon Barkley (groin) — Expected IN
Quinshon Judkins (shoulder) — IN
J.K. Dobbins (Foot) — Questionable

UPDATED: WEEK 10 FANTASY FOOTBALL RANKINGS

Week 10 WR Injuries

Chris Godwin (fibula) — OUT
Brian Thomas Jr. (ankle) — OUT
Terry McLaurin (Quad) — OUT
Ricky Pearsall (Knee) — OUT
Kayshon Boutte (Hamstring) — OUT
Isaiah Bond — OUT
Tory Horton (Groin/Shin) — Expected OUT
Matthew Golden (shoulder) — Questionable
Tet McMillian (Hamstring) — Questionable
Garrett Wilson (knee) — IN
Puka Nacua (Ribs) — IN
Cedric Tillman (hamstring) — IN
Dyami Brown (Concussion) — IN
Luther Burden III (concussion) — IN
Cooper Kupp (heel, hamstring) — Leaning IN
Dontayvion Wicks (calf) — Questionable
Joshua Palmer (knee, ankle) — Questionable
Brandon Aiyuk (Knee) — Estimated Week 11-13 Return

Week 10 TE Injuries

Cole Kmet (Concussion) — IN
Harold Fannin (Hamstring) — Questionable
Hunter Long (hip/knee) — OUT
Tucker Kraft (Knee) — OUT FOR SEASON
Josh Oliver — OUT
Daniel Bellinger (neck) — IN

Week 10 QB Injuries

C.J. Stroud (Concussion) — OUT
Jayden Daniels (Elbow) — OUT Indefinitely
Brock Purdy (Toe) — Mac Jones Will Start
Kyler Murray (Foot) — PLACED ON IR

WEEK 10 RED ZONE WATCH ALONG!!!!

WE’RE BACK AGAIN for Week 10 Redzone. If you’re looking to hang with someone when Week 10 kicks off, you can do it with me, Cust, and Friends live from MMN HQ.

We’ll be streaming RedZone and talking along over the RZ stream on Playback. Playback has the rights to RedZone, and we’ll be doing commentary while we all watch it together in perfect sync. It’ll be on YouTube as well, but we don’t have the rights to stream RedZone there, so it will just be us talking in the room. Still a good time btw.

SIGN UP FREE FOR PLAYBACK AND WATCH ALONG WITH THE PME CREW

Week 10 Best Bets

Mayo, Rob Pizzola, and Cam Stewart. We break down the full 2025 NFL Week 10 slate, with betting analysis, game previews, and our favorite teaser plays. Whether you’re looking for sharp betting edges, insights on key matchups, or value picks, this Week 10 betting guide has you covered.

WATCH: NFL Week 10 Best Bets, Teasers, Fastest 60s

GOLD

MAYO: NYG +5.5
PIZZOLA: BAL -4
CAM: BAL -4

SILVER

MAYO: CLE -2
PIZZOLA: MIA +10
CAM: NO +6

BRONZE

MAYO: LAC -2.5
PIZZOLA: HOU +1.5
CAM: DET -8

6-POINT GROUP TEASER: NE +8.5/DET -2/SEA -0.5

2025 Teaser Record: 5-4

Week 10 Spread Picks

Mayo, Geoff Fienberg, and Tim Anderson go game-by-game and make their 2025 Week 10 Spread Picks, Bets, Survivor Picks, and Props. Plus, a mini Cust Corner on Cust’s best sauce rankings.

MAYO: DEN -9, ATL +6, NYG +3.5, MIA +9.5, BAL -4, CLE -2, TB -2.5, NO +5, HOU -1.5, ARZ +6.5, SF +3.5, DET -8.5, LAC -3, PHI +2.5

GEOFF: DEN -9, ATL +6, CHI -3.5, BUF -9.5, BAL -4, CLE -2, NE +2.5, CAR -5, HOU -1.5, SEA -6.5, LAR -3.5, DET -8.5, PIT +3, PHI +2.5

CUST: DEN -9, ATL +6, NYG +3.5, MIA +9.5, MIN +4, CLE -2, NE +2.5, NO +5, JAX +1.5, SEA -6.5, LAR -3.5, DET -8.5, LAC -3, PHI +2.5

THE COIN: LV +9, IND -6, NYG +3.5, BUF -9.5, MIN +4, CLE -2, TB -2.5, CAR -5, JAX +1.5, SEA -6.5, LAR -3.5, WAS +8.5, PIT +3, GB -2.5

2025 RECORD (SEASON RECORD)

MAYO: 8-6 (65-67)
GEOFF: 9-5 (70-62)
CUST: 6-8 (80-52)
COIN: 9-5 (68-64)

SUPERLOCK (SEASON RECORD)

MAYO: NYG +3.5 (2-6)
GEOFF: CLE -2 (6-3)
CUST: PHI +2.5 (4-5)

CUST “FREE MONEY” PICKS

MONEY LINE: CLE/SEA/DET/PHI +475
Cust’s 2025 Record: 1-8
Cust’s Lifetime Record: 31–160

NFL Week 10 Prop Bets

I’ve worked with my pals at Coolbet to BOOST up a four-player prop parlay. If you’re in Canada (Outside Ontario), I’ll have boosted plays at Coolbet all season long. Highly recommend.

Get a the PME Exclusive Boosts at Coolbet

Remember to use the profit boosts in the Underdog lobby to get more value on every entry too! If you’re new to Underdog, code MAYO gets you a deposit bonus, the “Play $5 Get $50 in Bonus Funds to Play $5 Get $100 in Bonus Funds” offer. I played an alt prop entry, similar to the Coolbet parlay.

TAIL OR FADE + code “MAYO” at underdog for a deposit bonus up to $1000

Week 10 DraftKings Ownership

USE CODE “MAYO50” TO GET FREE 7 DAYS OF the 4for4 DFS Tools and Content+ 50% OFF MONTHLY PRICE

RBs Projected Ownership 18%+

WR Projected Ownership 18%+

TE Projected Ownership 10%+

QB Projected Ownership 10%+

DST Projected Ownership 8%+

Jaguars
Browns
Buccaneers

WEEK 10 SUNDAY NIGHT LIVE

Cust and I are going LIVE at 715pm ET on MMN Sunday for the INSTA RECAP with Garion Thorne. Join live and guess the Week 11 Spreads along with us and a viewer who is picking with us!

SET A REMINDER AND TUNE IN LIVE!!!!!

Week 10 Cheatsheet… But a different way

🏃‍♂️ RUNNING BACKS

Bucky Irving (TB) – OUT. Rashad White gets all the work vs. NE, but it’s a brutal matchup. Patriots’ run D has shut down RB1s all year. Mayo projects White under 43.5 rushing yards but still startable in full-PPR for his pass work.

Rhamondre Stevenson (NE) – OUT (toe). TreVeyon Henderson starts but faces a similar tough run front on the other side. Volume through the air > on the ground. Mayo leans under 44.5 rushing yards.

Aaron Jones (MIN) – Questionable (shoulder). Trending toward playing. If not, Jordan Mason moves up. Both sit in the RB20–RB30 range vs. an improving Ravens D.

DeAndre Swift (PHI) – Active (groin). Slightly preferred over Kyle Monangai (banged up) in a plus matchup vs. NYG. Both are “usable, not reliable” flexes.

Saquon Barkley (NYG) – Expected to play after a pre-bye groin tweak.

J.K. Dobbins (DEN) – Foot injury. Limited Thursday, may sit. Mayo notes “keep updated — he’s on borrowed time.”

Quinshon Judkins (CLE) – Full go. Heavy workload incoming vs. Jets. Mayo expects 20+ carries and features him in this week’s boosted Coolbet parlay (Judkins 70+ rush yards + CLE ML + Breece Hall under 65.5).

🎯 WIDE RECEIVERS

Buccaneers: Chris Godwin & Mike Evans – OUT. Emeka Egbuka steps into top-10 territory; Tez Johnson becomes a WR3 (WR34). Expect volume.

Terry McLaurin (WAS) – OUT. Chris Moore gets routes but limited ceiling with Marcus Mariota starting. Deep flyer: Jaylin Lane better option for a one-play splash.

Brandon Aiyuk (SF) – Still on IR. Return now projected Week 12-13 return. Jauan Jennings > Kendrick Bourne as the fill-in.

Kayshon Boutte (NE) – OUT (hamstring). More looks for Pop Douglas and limited Stefon Diggs (continued snap count). Douglas and Hunter Henry favored short-area targets.

Cedric Tillman (CLE) – Returning. QB play limits upside, but still more appealing than Jerry Jeudy: Drop Jeudy.

Tory Horton (SEA) – Likely OUT (groin/shin). Opens deep-shot role for Rashid Shaheed (new Seahawk) alongside returning Cooper Kupp.

Matthew Golden (GB) – Questionable (shoulder). Same for Dontayvion Wicks. Expect heavy Christian Watson + Romeo Doubs usage, plus more Luke Musgrave targets. Target share gets divided the if Golden and/or Wicks are active.

Tet McMillan (CAR) – Questionable (hamstring). If limited, Panthers’ passing game becomes “ugly.” Jalen Coker and Xavier Legette not trustworthy starts.

🧩 TIGHT ENDS

Harold Fannin (CLE) – Questionable (hamstring). Bumped outside top 10. If out, David Njoku slides into TE1 range.

Cole Kmet (CHI) – Cleared concussion protocol, full go. Loveland bumped down

Josh Oliver (MIN) – OUT. Slight bump for TJ Hockenson’s TD share.

Daniel Bellinger (NYG) – Back from neck injury. Will split time with Theo Johnson, capping both.

🧠 QUARTERBACKS

Jaden Daniels (WAS) – Out (elbow). Not on IR but expected to miss rest of season. Marcus Mariota starts.

C.J. Stroud (HOU) – Out (concussion). Davis Mills starts. Nico Collins or bust for HOU in Fantasy.

Kyler Murray (ARI) – Placed on IR (knee). Out 4–8 weeks. Jacoby Brissett starts vs. SEA; playable for volume if chasing points.

Brock Purdy (SF) – Out. Mac Jones starts, Purdy potentially active as emergency QB.

📊 MAYO’S PROP LEANS – UNDERDOG PICKS + PROPS

All “lower” plays this week:

Rachaad White – Under 43.5 Rush Yds
TreVeyon Henderson – Under 44.5 Rush Yds
Breece Hall – Under 63.5 Rush Yds
Emari DiMercado – Under 34.5 Rush Yds

Coolbet Boost: Judkins 70+ Rush Yds + CLE ML + Hall Under 65 = +300
(Available for Canadians outside Ontario)

DRAFTKINGS + DFS

Week 10 sets up as one of the trickier DFS slates of the season. The chalk is very clear, but the paths to leverage are equally obvious. There are no cheap RB values this week. You’re either paying up, or you’re getting creative in the mid-tier.

If you’re playing tournaments, focus on ownership leverage and game stacks with condensed usage. All ownership projections and Sims data are live at 4for4.com/mayo (use code MAYO50 for a 7-day trial).

🏃‍♂️ Running Backs

💥 Chalk Trio:

Rico Dowdle (DAL) – $6.3K | ~38% owned
Christian McCaffrey (SF) – $9K | ~30%
De’Von Achane (MIA) – $7.4K | ~27%

They’re the clear top plays — but you’ll see all three jammed into the same builds. Or at least 2 of the 3.

🚫 Mayo’s Fade:
Dowdle – He’s great, but everyone will have him. I’d rather pivot to Kyren or Judkins and hope for the touchdowns. Gotta live on the edge sometimes. However, know it feels stupid when he’s the slate breaker.

⚡ Tournament Leverage:

DeAndre Swift – $6,100 | ~5% – Quietly in a solid matchup. “Better spot than people realize.”
Quinshon Judkins – $6,300 | ~14% – Massive workload projection vs. Jets.
David Montgomery – $5,000 | ~7% – Probably the best cheap play on the board. Eight-point favorite. Great script. Just need him to get those high-leverage touches.

Stack note: Pairing Montgomery with Lions D/ST as a value correlation.

🎯 Wide Receivers

Top:
Amon-Ra St. Brown, Puka Nacua, and JSN are elite, but expensive. You can’t afford more than one without a cheap QB stack.

Cheaper, low-owned plays: