2025 NFL Week 6 Weekend Cheatsheet: Updated Rankings, Injuries, Player Props | DraftKings Picks, Ownership, Values

Oct 11, 2025

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WEEK 6 RED ZONE WATCH ALONG!!!!

WE’RE BACK AGAIN for Week 6 Redzone. If you’re looking to hang with someone when Week 6 kicks off, you can do it with me, Cust, and Friends live from MMN HQ.

We’ll be streaming RedZone and talking along over the RZ stream on Playback. Playback has the rights to RedZone, and we’ll be doing commentary while we all watch it together in perfect sync. It’ll be on YouTube as well, but we don’t have the rights to stream RedZone there, so it will just be us talking in the room. Still a good time btw.

SIGN UP FREE FOR PLAYBACK AND WATCH ALONG WITH THE PME CREW

Mayo updates his 2025 Fantasy Football Week 6 rankings with the latest news and goes through the Week 6 NFL Injury Report, telling you who is in and out and which players stand to benefit. Mayo then goes through his favorite Week 6 Props and fills out an Underdog Pick’em Entry before getting to his Top Cheap Plays on DraftKings for Week 6 at each position.

WATCH: NFL Week 6 Weekend Cheatsheet: Updated Rankings, Injuries, Player Props | DraftKings Picks Ownership, Values

Week 6 RB Injuries

Jaylen Warren (Knee) — IN
Chuba Hubbard (Calf) — OUT
Chris Rodriguez (calf) — Leaning OUT
Bucky Irving (Ankle) — OUT
Aaron Jones (Hamstring) — IR; OUT at least 1 More Week
Trey Benson (Knee) — IR; OUT at least 3 Weeks
Omarion Hampton (Ankle) —Placed on IR; OUT at least 4 Games
Miles Sanders (Ankle) — OUT FOR SEASON
Antonio Gibson (Knee) — OUT FOR THE SEASON

READ: UPDATED Week 6 RANKINGS BY POSITION

Week 6 WR Injuries

Allen Lazard (Personal) — OUT
Darnell Mooney (hamstring) — OUT
Zay Flowers (Shoulder) — Leaning IN
Jalen Coker (Quad) — OUT
Chris Godwin (Fibula) — OUT, likely multiple weeks
CeeDee Lamb (Ankle) — OUT
Mike Evans (Hamstring) — OUT
Christian Watson (knee) — OUT
Ricky Pearsall (Knee) — OUT
Terry McLaurin (Quad) — OUT
KaVontae Turpin (Foot) — OUT
Calvin Austin — OUT
Noah Brown (Groin) — OUT
Quentin Johnston (hamstring) — Questionable
Alec Pierce (Concussion) — IN
Jauan Jennings (Ankle/Shoulder) — Leaning IN
Curtis Samuel (neck/ribs) — Questionable
Cedric Tillman (Hamstring) — Placed on IR; OUT at least 4 Weeks
Brandon Aiyuk (Knee) — Practice Window Unlikely to be Opened Yet
Darius Slayton (hamstring) — DNP

Week 6 TE Injuries

Brock Bowers (Knee) — OUT
Michael Mayer (Concussion) — IN
Dalton Kincaid (Oblique) — Questionable
Colston Loveland (hip) — Leaning IN
Ja'Tavion Sanders (Ankle) — Leaning IN
George Kittle (Hamstring) — Expected OUT
Brenton Strange (Hip) — Placed on IR

Week 6 QB Injuries

Lamar Jackson (Hamstring) — OUT
Tua Tagovailoa’s (Hip) — Questionable
Brock Purdy (Toe) — OUT
Joe Flacco (TRADED TO CIN) — Starting over Browning
Kyler Murray (foot) — Questionable

Week 6 Best Bets

Mayo, Rob Pizzola, and Cam Stewart. We break down the full 2025 NFL Week 6 slate, with betting analysis, game previews, and our favorite teaser plays. Whether you’re looking for sharp betting edges, insights on key matchups, or value picks, this Week 6 betting guide has you covered.

WATCH: NFL Week 6 Best Bets, Teasers, Survivor Picks

GOLD

MAYO: IND -6.5
PIZZOLA: KC -1.5
CAM: SEA +1.5

SILVER

MAYO: LAR -7
PIZZOLA: GB -14
CAM: LV -3.5

BRONZE

MAYO: CLE +6.5
PIZZOLA: CHI +4.5
CAM: LAC -3.5

6-POINT GROUP TEASER: IND -0.5/SEA +7.5/LAR -0.5

2025 Teaser Record: 3-2

NFL Week 6 Spread Picks Cheatsheet

Mayo, Geoff Fienberg, and Tim Anderson go game-by-game and make their 2025 Week 6 Spread Picks, Bets, and Survivor Picks while previewing every NFL Week 6 game. Plus, a mini Cust Corner on Bowling, Regifting, and earlier start times.

WATCH: NFL Week 6 Spread Picks, Survivor Picks, Game Previews| Cust Corner: Halloween Fun, Monopoly Sticker Breaks

MAYO: PHI -7.5, NYJ +7.5, IND -6.5, NE -3.5, CLE +5, LAC -4.5, DAL -3, SEA -1, LAR -7.5, LV -4.5, CIN +14, SF +3, KC -2.5, ATL +4.5, CHI +4.5

GEOFF: PHI -7.5, NYJ +7.5, ARZ +6.5, NE -3.5, CLE +5, LAC -4.5, DAL -3, SEA -1, LAR -7.5, LV -4.5, GB -14, TB -3, KC -2.5, ATL +4.5, CHI +4.5

CUST: PHI -7.5, DEN -7.5, ARZ +6.5, NE -3.5, PIT -5, LAC -4.5, DAL -3, JAX +1, LAR -7.5, TEN +4.5, GB -14, TB -3, DET +2.5, ATL +4.5, CHI +4.5

THE COIN: PHI -7.5, DEN -7.5, IND -6.5, NO +3.5, CLE +5, MIA +4.5, CAR +3, SEA -1, LAR -7.5, TEN +4.5, GB -14, SF +3, KC -2.5, BUF -4.5, WAS -4.5

2025 RECORD (SEASON RECORD)

MAYO: 5-9 (35-40)
GEOFF: 7-7 (34-41)
CUST: 9-5 (45-30)
COIN: 3-11 (38-38)

SURVIVOR: (USED)

MAYO: OUTTTTT (DEN, BAL,SEA, GB)
GEOFF: OUTTTTT (PHI, ARZ, SEA, DEN, LAR)
CUST: OUTTTTT (PHI, ARZ ,TB, HOU, LAR)

SUPERLOCK (SEASON RECORD)

MAYO: IND -6.5 (0-4)
GEOFF: LV -4.5 (3-2)
CUST: DAL -3 (2-3)

CUST “FREE MONEY” PICKS

MONEY LINE PARLAY: PHI/DEN/GB/NE/DAL
Cust’s 2025 Record: 0-5
Cust’s Lifetime Record: 31–157

NFL Week 6 Prop Bets

I’ve worked with my pals at Coolbet to get a four-leg props parlay boosted up. If you’re in Canada (Outside Ontario), I’ll have boosted plays at Coolbet all season long. Highly recommend.

Get a the PME Exclusive Boosts at Coolbet

I’ve played a similar entry on Underdog, but didn’t adjust the lines at all, which makes it good enough for a 12.72 payout. There’s currently a 75% boost in the Underdog lobby, which you can use to take on adjusted lines with these (or whatever you wanna play). That boost is good through SNF. If you’re new to Underdog, code MAYO gets you a deposit bonus, the “Play $5 Get $50 in Bonus Funds to Play $5 Get $100 in Bonus Funds” offer.

TAIL OR FADE + code “MAYO” at underdog for a deposit bonus up to $1000

If you’re not confident in my ball-knowing (or lack thereof), I suggest getting the computer to find you the best values. This is where Sharp Stack has been printing. And I got some deals for you!

USE CODE “MAYO50” TO GET FREE 7 DAYS OFTHE SHARP STACK BETTING TOOL 50% OFF MONTHLY PRICE

Week 6 DraftKings Ownership

Mayo, Tyler Tamboline, and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 6 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 6. Whether you’re entering GPPs or cash games, this guide has you covered.

WATCH: NFL Week 6 DraftKings Picks 2025 | Best DFS NFL Lineups, Stacks, Ownership Projections

RBs Projected Ownership 18%+

WR Projected Ownership 18%+

TE Projected Ownership 10%+

QB Projected Ownership 10%+

DST Projected Ownership 8%+

WEEK 6 SUNDAY NIGHT LIVE

Cust and I are going LIVE at 715pm ET on MMN Sunday for the INSTA RECAP with friend of the show Jeff Erickson. Join live and guess the Week 7 Spreads along with us.