Week 5 NFL Weekend Cheatsheet: Rankings, Injuries, Props, DraftKings Picks/Ownership

Oct 04, 2025

Rich Storry-Imagn Images

Mayo updates his 2025 Fantasy Football Week 4 rankings with the latest news and goes through the Week 5 NFL Injury Report, telling you who is in and out and which players stand to benefit. Mayo then goes through his favorite Week 5 Props and fills out an Underdog Pick’em Entry before getting to his Top Cheap Plays on DraftKings for Week 5 at each position.

WATCH: NFL Week 5 Cheatsheet: Updated Rankings, Injuries, Player Props | DraftKings Picks Ownership, Values

Week 5 RB Injuries

Chuba Hubbard (Calf) — OUT
Bucky Irving (Ankle) — OUT
Miles Sanders (Ankle) — Questionable
Tyjae Spears (Ankle) — Leaning IN
Tyrone Tracy (Shoulder) — Expected OUT
Aaron Jones (Hamstring) — IR; OUT at least 2 More Games
Trey Benson (Knee) — Placed on IR; OUT at least 4 Weeks
Braelon Allen (Knee) — Placed on IR

READ: UPDATED WEEK 5 RANKINGS BY POSITION

Week 5 WR Injuries

Deebo Samuel (Heel) — Expected IN
Michael Pittman (Hamstring) — Expected IN
Jonathan Mingo (Knee) — Questionable
Calvin Ridley (Knee) — Questionable
Xavier Legette (Hamstring) — Expected IN
Kavontae Turpin (Foot) — OUT
CeeDee Lamb (Ankle) — OUT 1-4 Weeks
Mike Evans (Hamstring) — OUT 1-4 Weeks
Terry McLaurin (Quad) — OUT
Noah Brown (Groin) — OUT
Alec Pierce (Concussion) — OUT
Ricky Pearsall (Knee) — DNP
Jauan Jennings (Ankle/Shoulder) — DNP
Cedric Tillman (Hamstring) — Placed on IR; OUT at least 4 Weeks
Tyreek Hill (Knee) — OUT FOR SEASON
Malik Nabers (Knee) — OUT FOR SEASON
Jalen Coker (Quad) — Practice Window to be Opened
Brandon Aiyuk (Knee) — Practice Window Unlikely to be Opened

Week 5 TE Injuries

Brock Bowers (Knee) — Leaning OUT
Dallas Goedert (Knee) — Expected IN
Taysom Hill (Knee) — Expected IN
Foster Moreau — Expected IN
Michael Mayer (Concussion) — OUT
Will Dissly (Knee) — Leaning IN
Noah Fant (Concussion) — Expected IN
Ja'Tavion Sanders (Ankle) — OUT 1-4 Weeks
George Kittle (Hamstring) — OUT 1-4 Weeks

Week 5 QB Injuries

Lamar Jackson (Hamstring) — OUT 1-3 Weeks
Jayden Daniels (Knee) — IN
JJ McCarthy (Ankle) — Expected OUT
Joe Flacco BENCHED — Dillon Gabriel to Start
Brock Purdy (Toe) — DNP; Leaning OUT Week 6

RED ZONE WATCH ALONG!!!!

After that week’s successful launch, WE’RE BACK for Week 5 Redzone. If you’re looking to hang with someone when Week 5 kicks off, you can do it with me, Cust, and Friends live from MMN HQ. We’ll be streaming RedZone and talking along over the RZ stream on Playback. Playback has the rights to RedZone, and we’ll be doing commentary. We’ll be doing it on YouTube as well, but we don’t have the rights to stream RedZone there, so it will just be us talking in the room.

SIGN UP FREE FOR PLAYBACK AND GET A PME VIP BADGE TO WATCH ALONG

Week 5 Best Bets

Mayo, Rob Pizzola, and Cam Stewart. We break down the full 2025 NFL Week 5 slate, with betting analysis, game previews, and our favorite teaser plays. Whether you’re looking for sharp betting edges, insights on key matchups, or value picks, this Week 5 betting guide has you covered.

WATCH: NFL Week 5 Best Bets, Teasers, Survivor Picks

GOLD

MAYO: ARZ -7
PIZZOLA: NYJ +2.5
CAM: JAX +3.5

SILVER

MAYO: NYG +2.5
PIZZOLA: HOU -1
CAM: CAR +1.5

BRONZE

MAYO: IND -6.5
PIZZOLA: DEN +3.5
CAM: BUF -7.5

6-POINT GROUP TEASER: BUF -1.5/WAS +9/IND -0.5
2025 Teaser Record: 3-1

Oh, and if you want all Cam’s picks, get them in the FASTEST 60s IN SPORTS BETTING

NFL Week 5 Spread Picks Cheatsheet

Mayo, Geoff Fienberg, and Tim Anderson go game-by-game and make their 2025 Week 5 Spread Picks, Bets, Survivor Picks, and Props. Plus, a mini Cust Corner on Pre Drinking, Costco Meals, McDonalds Monopoly.

WATCH: Week 5 Spread Picks, Survivor | Cust Corner: Pre Drinking, Costco Meals, McDonalds Monopoly

MAYO: LAR -6, CLE +3.5, IND -6.5, NYJ +3, BAL +2.5, NYG +2, CAR +1.5, PHI -3.5, ARZ -8.5, WAS +3, DET -10, TB +3.5, BUF -7.5, KC -3.5

GEOFF: LAR -6, MIN -3.5, IND -6.5, NYJ +3, BAL +2.5, NO -2, MIA -1.5, DEN +3.5, ARZ -8.5, WAS +3, DET -10, SEA -3.5, BUF -7.5, JAX +3.5

CUST: LAR -6, MIN -3.5, IND -6.5, DAL -3, HOU -2.5, NO -2, MIA -1.5, PHI -3.5, ARZ -8.5, LAC -3, DET -10, TB +3.5, NE +7.5, JAX +3.5

THE COIN: LAR -6, CLE +3.5, LV +6.5, DAL -3, BAL +2.5, NYG +2, CAR +1.5, PHI -3.5, ARZ -8.5, WAS +3, CIN +10, SEA -3.5, BUF -7.5, JAX +3.5

2025 RECORD (SEASON RECORD)

MAYO: 4-12 (30-32)
GEOFF: 6-10 (27-34)
CUST: 12-4 (37-25)
COIN: 12-4 (35-27)

SURVIVOR: (USED)

MAYO: OUTTTTT (DEN, BAL,SEA, GB)
GEOFF: LAR (PHI, ARZ,SEA, DEN)
CUST: LAR (PHI,ARZ,TB, HOU)

SUPERLOCK (SEASON RECORD)

MAYO: ARZ -8.5 (0-3)
GEOFF: MIN -3.5 (2-2)
CUST: LAR -6 (2-2)

CUST “FREE MONEY” PICKS

6-POINT TEASER: LAR PK/IND -0.5/ARZ -2.5/DET -4 +240

Cust’s 2025 Record: 0-4
Cust’s Lifetime Record: 31–156

NFL Week 5 Prop Bets & Underdog Pick'em

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TAIL OR FADE + code “MAYO” at underdog for a deposit bonus up to $1000

And since there’s a London game, why not get some action in early?

TAIL OR FADE + code “MAYO” at underdog for a deposit bonus up to $1000

If you’re not confident in my ball-knowing (or lack thereof), I suggest getting the computer to find you the best values. This is where Sharp Stack has been printing. (As it was Saturday for CBF) And I got some deals for you!

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Some other props I went in on…

Jalen Tolbert o3.5 Receptions
Cooper Rush u4.5 Rushing Yards
Chase Brown u51.5 Rushing Yards
Ja’Marr Chase o66.5 Receiving Yards
Jameson Williams o22.5 Longest Reception
Quentin Johnston o23.5 Longest Reception
Jaxson Dart o38.5 Rushing Yards
Tommy Tremble o2.5 Receptions

Week 5 DraftKings Ownership

Mayo, Tyler Tamboline, and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 5 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 5. Whether you’re entering GPPs or cash games, this guide has you covered.

WATCH: NFL Week 5 DraftKings Picks 2025 | Best DFS NFL Lineups, Ownership Projections

RBs Projected Ownership 18%+

WR Projected Ownership 18%+

TE Projected Ownership 10%+

QB Projected Ownership 10%+

DST Projected Ownership 8%+

Team Passing Stacks Combined Projected Ownership 35%+

Team Passing Stacks Lowest Projected Ownership <15%

SUNDAY NIGHT LIVE

Cust and I are going LIVE at 715pm ET on MMN Sunday for the INSTA RECAP, featuring the RETURN OF Garion Thorne!!!! Come for some laughs and play guess the spreads along with the gang.