2025 Week 16 NFL Weekend Cheatsheet: Injuries, Picks, DFS, Props, Updated Rankings

Patrick Mayo

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Dec 21, 2025

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2025 Week 16 NFL Weekend Cheatsheet

Week 16 RB Injuries

Bhayshul Tuten (Finger) — OUT
Alvin Kamara (Knee) — OUT
Dylan Sampson — OUT
Jerome Ford — OUT
Josh Jacobs (Knee) — Questionable
Nick Chubb (ribs) — Leaning IN
Woody Marks (Ankle) — Leaning IN
RJ Harvey (ribs) — IN
Chris Rodriguez (groin) — IN
Devin Neal (hamstring) — OUT FOR SEASON
Zonovan Knight (knee) — OUT FOR SEASON

UPDATED: WEEK 16 FANTASY FOOTBALL RANKINGS

Week 16 WR Injuries

Devaughn Vele (shoulder) — OUT
Rashee Rice (Concussion) — OUT
Tyquan Thornton (Concussion) — OUT
Luther Burden (ankle) — OUT
Rome Odunze (Foot) — OUT
Ricky Pearsall (knee) — Leaning OUT
Tee Higgins (Concussion) — Leaning IN
Quentin Johnston (groin) — Questionable
Drake London (Knee) — Leaning IN
Pat Bryant (hamstring) — IN
Hollywood Brown (personal) — IN
Christian Watson (chest) — Leaning IN
Marvin Harrison Jr. (heel) — Leaning IN
Davante Adams (Hamstring) — DNP
Garrett Wilson (knee) — OUT FOR SEASON
Noah Brown (Ribs) — OUT FOR SEASON

Week 16 TE Injuries

Mason Taylor (Neck) — OUT
David Njoku (knee) — OUT
Noah Fant — OUT
Cade Otton (Knee) — IN
Dalton Kincaid (Knee) — IN

Week 16 QB Injuries

Geno Smith (Shoulder) — IN
Tyrod Taylor (Groin) — Brady Cook Will Start
Tua Tagovailoa (BAD) — Quinn Ewers
Jordan Love (Concussion) — Exited Game
Marcus Mariota (Concussion) — Exited Game
Jayden Daniels (Elbow) — OUT FOR SEASON
Patrick Mahomes (Knee) — OUT FOR SEASON

Week 16 Best Bets

Mayo, Rob Pizzola, and Cam Stewart. We break down the full 2025 NFL Week 16 slate, with betting analysis, game previews, and our favorite teaser plays. Whether you’re looking for sharp betting edges, insights on key matchups, or value picks, this Week 16 betting guide has you covered.

WATCH: NFL Week 16 Best Bets, Teasers, Fastest 60s

GOLD

MAYO: SF -6
PIZZOLA: ATL -2.5
CAM: JAX +3

SILVER

MAYO: DET -6.5
PIZZOLA: CAR +3
CAM: GB +1.5

BRONZE

MAYO: HOU -13.5
PIZZOLA: MIA +4.5
CAM: DAL -1.5

6-POINT GROUP TEASER: DET -0.5/SF PK/NE +9

2025 Teaser Record: 9-6

Week 16 Spread Picks

Pat Mayo, Geoff Fienberg, and Tim Anderson go game-by-game and make their 2025 Week 16 Spread Picks, Bets, Survivor Picks, and chat all things NFL. Plus, a mini Cust Corner on Ice Cream, Meatball, Famous Steve Austins.

WEEK 16 NFL PICKS CHEATSHEET

MAYO: LAR -1, WAS +6.5, CHI +1, BUF -10, DAL -2, KC -3.5, MIA +2.5, NO -4.5, NYG +3, CAR +3, DEN -3, ARZ +2.5, DET -7, HOU -14.5, NE +2.5, SF -6

GEOFF: SEA +1, PHI -6.5, CHI +1, BUF -10, DAL -2, TEN +3.5, CIN -2.5, NO -4.5, MIN -3, TB -3, JAX +3, ATL -2.5, DET -7, HOU -14.5, BAL -2.5, IND +6

CUST: SEA +1, WAS +6.5, GB -1, BUF -10, LAC +2, KC -3.5, MIA +2.5, NO -4.5, MIN -3, TB -3, JAX +3, ARZ +2.5, DET -7, LV +14.5, NE +2.5, IND +6

THE COIN: SEA +1, PHI -6.5, GB -1, CLE +10, LAC +2, TEN +3.5, CIN -2.5, NO -4.5, MIN -3, TB -3, DEN -3, ARZ +2.5, DET -7, HOU -14.5, NE +2.5, IND +6

2025 RECORD (SEASON RECORD)

MAYO: 5-11 (97-121)
GEOFF: 10-6 (117-101)
CUST: 8-8 (121-97)
COIN: 6-10 (109-109)

SUPERLOCK (SEASON RECORD)

MAYO: SF -6 (3-11)
GEOFF: DET -7 (10-5)
CUST: DET -7 (6-8)

CUST “FREE MONEY” PICKS

6-POINT TEASER: BUF -4/JAX +9/NE +8.5/DET -7
Cust’s 2025 Record: 3-13
Cust’s Lifetime Record: 32–164

NFL Week 16 Props Bets

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Week 16 DraftKings Values & Ownership

Pat Mayo, Tyler Tamboline, and John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 16 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, and fades for Week 16. Whether you’re entering GPPs or cash games, this guide has you covered.

RBs Projected Ownership 18%+

USE CODE “MAYO” TO GET FREE 7 DAYS OF the 4for4 DFS Tools and Content+ 50% OFF MONTHLY PRICE

WR Projected Ownership 18%+

TE Projected Ownership 10%+

Harold Fannin Jr.
Travis Kelce

QB Projected Ownership 10%+

DST Projected Ownership 8%+

WEEK 16 SUNDAY NIGHT LIVE

Pat Mayo, Cust, and Cam Stewart break down the biggest storylines, instant recap, and betting takeaways from Sunday’s slate. Plus, Week 15 Sunday Night Football features NE at BAL — we’ve got our picks, leans, and best bets.