Week 4 NFL Cheatsheet: Rankings, Injuries, Props, DraftKings Picks/Ownership

Sep 27, 2025

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Mayo updates his 2025 Fantasy Football Week 4 rankings with the latest news and goes through the Week 4 NFL Injury Report telling you who is in and out and which players stand to benefit. Mayo then goes through his favorite Week 4 Props and fills out an Underdog Pick’em Entry before getting to his Top Cheap Plays on DraftKings for Week 4 at each position.

WATCH: NFL Week 4 Cheatsheet: Updated Rankings, Injuries, Player Props | DraftKings Picks Ownership, Values

Week 4 RB Injuries

Tyrone Tracy (Shoulder) — OUT 2-4 Weeks
Aaron Jones (Hamstring) — IR; OUT at least 3 More Games
Will Shipley (Ribs) — IN
Jacory Croskey-Merritt (knee) — Leaning IN

READ: UPDATED WEEK 4 RANKINGS BY POSITION

Week 4 WR Injuries

Davante Adams (Hamstring) — Questionable
Jauan Jennings (Ankle/Shoulder) — Questionable
CeeDee Lamb (Ankle) — OUT 2-4 Weeks
Mike Evans (Hamstring) — OUT 2-4 Weeks
Chris Godwin — Questionable
Terry McLaurin (Quad) — OUT
Alec Pierce (Concussion) — OUT
Noah Brown (Groin) — Leaning OUT
Xavier Legette (Hamstring) — OUT
Dyami Brown (shoulder) — Leaning IN
Xavier Worthy (Shoulder) — IN; Potentially Limited
Josh Reynolds (Hamstring) — IN
Jordan Addison (Suspension) — Returning From Suspension
DeMarcus Robinson (Suspension) — Returning From Suspension

Week 4 TE Injuries

Michael Mayer (Concussion) — OUT
Ja'Tavion Sanders (Ankle) — OUT 2-4 Weeks
Will Dissly (Knee) — OUT
George Kittle (Hamstring) — OUT Another 1-4 Weeks
Isaiah Likely (Foot) — Leaning IN
Noah Fant (Concussion) — OUT
Tyler Higbee (hip) — Leaning IN
Colston Loveland (Hip) — Expected OUT
Evan Engram (Back) — IN
Darren Waller (hip) — Leaning IN

Week 4 QB Injuries

Jayden Daniels (Knee) — OUT
J.J. McCarthy (Ankle) — OUT 1-4 Weeks
Justin Fields (Concussion) — IN
Brock Purdy (Shoulder/Toe) — IN

Week 4 Best Bets

Mayo, Rob Pizzola, and Cam Stewart. We break down the full 2025 NFL Week 4 slate, with betting analysis, game previews, and our favorite teaser plays. Whether you’re looking for sharp betting edges, insights on key matchups, or value picks, this Week 4 betting guide has you covered.

WATCH: NFL Week 4 Best Bets, Teasers, Survivor Picks

GOLD

MAYO: GB -6.5
PIZZOLA: LV +1.5
CAM: NYJ +3

SILVER

MAYO: PHI -3.5
PIZZOLA: NE -4.5
CAM: DEN -7

BRONZE

MAYO: BAL -2.5
PIZZOLA: MIN -2
CAM: ATL +1.5

6-POINT GROUP TEASER: LAC -0.5/NE +1.5/ATL +7.5
2025 Teaser Record: 3-0

RED ZONE WATCH ALONG!!!!

If you’re looking to hang with someone when Week 4 kicks off, you can do it with Cust and I. We’ll be streaming RedZone and talking along over the RZ stream on Playback. Playback has the rights to RedZone and we’ll be doing commentary. It’s a trial so it’s only open to 100 people in Week 4. If you sign up (it’s free) I’ll get you a VIP Badge and you can watch along with us. Maybe even join in the stream. If it goes well and we get enough people, we may keep it going every week.

SIGN UP FREE FOR PLAYBACK AND GET A PME VIP BADGE TO WATCH ALONG

NFL Week 4 Spread Picks Cheatsheet

Mayo, Geoff Fienberg and Tim Anderson go game-by-game and make their 2025 Week 4 Spread Picks, Bets, Survivor Picks while previewing every NFL Week 4 game. Plus, a mini Cust Corner on Bowling, Regifting, and earlier start times.

WATCH: NFL Week 4 Spread Picks, Survivor Picks, Ryder Cup | Cust Corner: Bowling, Regifting

MAYO: ARZ +1, MIN -2.5, LAC -6.5, ATL +1.5, BUF -16.5, CLE +8.5, PHI -3.5, CAR +5.5, TEN +7, IND +3.5, SF -3, BAL -2.5, LV -1, GB -6.5, MIA -2.5, CIN +7

GEOFF: ARZ +1, MIN -2.5, LAC -6.5, ATL +1.5, BUF -16.5, DET -8.5, PHI -3.5, NE -5.5, TEN +7, LAR -3.5, SF -3, BAL -2.5, LV -1, GB -6.5, NYJ +2.5, DEN -7

CUST: SEA -1, PIT +2.5, LAC -6.5, ATL +1.5, NO +16.5, DET -8.5, PHI -3.5, NE -5.5, HOU -7, IND +3.5, JAX +3, KC +2.5, CHI +1, GB -6.5, NYJ +2.5, DEN -7

THE COIN: SEA -1, MIN -2.5, NYG +6.5, ATL +1.5, NO +16.5, CLE +8.5, PHI -3.5, NE -5.5, HOU -7, LAR -3.5, SF -3, KC +2.5, CHI +1, DAL +6.5, NYJ +2.5, DEN -7

2025 LAST WEEK RECORD (SEASON RECORD)

MAYO: 9-7 (26-20)
GEOFF: 9-7 (21-24)
CUST: 8-8 (25-21)
COIN: 8-8 (23-23)

SURVIVOR: (USED)

MAYO: GB (DEN, BAL,SEA)
GEOFF: DEN (PHI, ARZ,SEA)
CUST: HOU (PHI,ARZ,TB)

SUPERLOCK (SEASON RECORD)

MAYO: GB -6.5 (0-2)
GEOFF: NE -5.5 (1-2)
CUST: PIT +2.5 (1-2)

CUST “FREE MONEY” PICKS

MONEY LINE PARLAY: PIT/LAC/DET/HOU/GB +514

Cust’s 2025 Record: 0-3
Cust’s Lifetime Record: 31–155

NFL Week 4 Prop Bets

I’ve worked with my pals at Coolbet to get a four-leg props parlay boosted up. If you’re in Canada (Outside Ontario), I’ll have boosted plays at Coolbet all season long. Highly recommend.

Get the PME Exclusive Boosts at Coolbet

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TAIL OR FADE + code “MAYO” at underdog for a deposit bonus up to $1000

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Week 4 DraftKings Ownership

Mayo and Tyler Tamboline (John Breslin of 4for4 DFS Fantasy will return next week) break down the best 2025 NFL Week 4 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 4. Whether you’re entering GPPs or cash games, this guide has you covered.