2025 Week 2 NFL Cheatsheet: Injuries, Picks, DFS, Props, Fantasy Rankings

Sep 13, 2025

WEEK 2 NFL WEEKEND CHEATSHEET

Pat Mayo updates his 2025 Fantasy Football Week 2 rankings with the latest news and goes through the Week 2 NFL Injury Report telling you who is in and out and which players stand to benefit and a deeper dive on what to do with Brock Bowers on Monday Night Football if we don’t have a firm answer on whether or not he’ll be active (He’s currently leaning IN for MNF).

Plus, a look at how the Austin Ekeler & Jayden Reed injuries from TNF will affcet both offennes. Mayo then goes through his favorite Week 2 Props and fills out an Underdog Pick’em Entry before getting to his Top Cheap Plays on DraftKings for Week 2 at each position along with projected ownership for the main slate.

WATCH: NFL Week 2 Cheatsheet: Fantasy Rankings, Injuries, Underdog Picks, Props | DraftKings Value Plays

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NFL Injury Report

RB

Austin Ekeler (Achilles) — OUT FOR SEASON
Quinshon Judkins (Issues) — IN
Roschon Johnson (foot) — IN
Will Shipley (Ribs) — OUT
Jaylen Wright (Leg) — Leaning OUT

LIST: UPDATED Week 2 Rankings By Positon

WR

Jayden Reed (shoulder) — OUT 6-8 Weeks
WanDale Robinson (ankle) — Likely IN
Drake London (Shoulder) — IN
Darnell Mooney (Shoulder) — IN
Jauan Jennings (left shoulder) — Questionable
Xavier Worthy (Shoulder) — OUT
Christian Kirk (Hamstring) — OUT
Jake Bobo (Concussion) — IN
Josh Reynolds (Hamstring) — OUT
Jalen Royals (Knee) — OUT

TE

Brock Bowers (Knee) — Questionable (MNF); Leaning IN
George Kittle (Hamstring) — OUT 3-5 Weeks
Dallas Goedert (Knee) — OUT
Evan Engram (Calf) — IN
Isaiah Likely (Foot) — OUT
Darren Waller (Hip) — OUT

QB

Brock Purdy (Shoulder/Toe) — OUT Multiple Weeks; Mac Jones to Start

NFL Week 2 Spread Picks & Survivor

WATCH: Spread Picks, Survivor Picks | Cust Corner: Construction Delays & Grocery Flyers

WEEK 2 NFL PICKS CHEATSHEET

MAYO: GB -3.5, NE +1.5, NYG +5.5, CHI +5.5, TEN +5.5, BUF -7, SF -4.5, PIT -3, CLE +11, CIN -3.5, DEN -2, CAR +6.5, PHI -1, ATL +4.5, HOU -2.5, LV +3.5

GEOFF: WAS +3.5, NE +1.5, DAL -5.5, CHI +5.5, TEN +5.5, NYJ +7, SF -4.5, SEA +3, CLE +11, JAX +3.5, IND +2, CAR +6.5, PHI -1, ATL +4.5, HOU -2.5, LV +3.5

CUST: WAS +3.5, MIA -1.5, DAL -5.5, DET -5.5, TEN +5.5, NYJ +7, NO +4.5, SEA +3, BAL -11, CIN -3.5, IND +2, ARZ -0.5, KC +1, ATL +4.5, TB +2.5, LAC -3.5

THE COIN: WAS +3.5, MIA -1.5, DAL -5.5, CHI +5.5, LAR -5.5, BUF -7, SF -4.5, SEA +3, CLE +11, JAX +3.5, DEN -2, ARZ -0.5, KC +1, ATL +4.5, HOU -2.5, LAC -3.5

2025 RECORD

MAYO: 8-6

GEOFF: 6-8

CUST: 9-5

COIN: 9-5

SURVIVOR: (USED)

MAYO: BAL (DEN)

GEOFF: ARZ (PHI)

CUST: ARZ (PHI)

SUPERLOCK (SEASON RECORD)

MAYO: TEN +5.5 (0-0)

GEOFF: SF -4.5 (0-1)

CUST: TB +2.5 (0-1)

CUST “FREE MONEY” PICKS

6 POINT TEASER: WAS +9.5/NYJ +12.5/ARZ -0.5/KC +7/TB +8.5

Cust’s 2025 Record: 0-1

Cust’s Lifetime Record: 31–153

NFL Week 2 Best Bets

Cam may be developing an addiction to betting the Giants much like he did to the Panthers a year ago early in the season.

WATCH: Best Bets, Teasers, Survivor Picks | NFL Picks & Game Previews

GOLD

MAYO: NE +1.5
PIZZOLA: SEA +3
CAM: NYG +5.5

SILVER

MAYO: PHI -1
PIZZOLA: SF -3
CAM: TEN +6

BRONZE

MAYO: CIN -3.5
PIZZOLA: CAR +7
CAM: SEA +3

6-POINT GROUP TEASER: NE +7.5/TB +8.5/SEA +9

2025 BEST BETS RECORD

MAYO: GOLD (0-0); SILVER (1-0); BRONZE (0-1)
PIZZOLA: GOLD (1-0); SILVER (0-1); BRONZE (0-1)
CAM: GOLD (0-1); SILVER (1-0); BRONZE (1-0)
TEASER: 1-0

REMINDER: Always use the Odds Screen in the Sharp Stack Tool from 4for4 to get the best number and price on every game.

USE CODE MAYO TO GET THE SHARP STACK BETTING TOOL 7-DAY FREE TRIAL THEN 25% OFF

WEEK 2 UNDERDOG PROPS

Some of the players I want to target haven’t popped yet on Underdog (mainly Dare Ogunbowale over receptions vs TB who can’t guard RBs), so I decided to script out on entry based on my thought KC will be trailing PHI for at least a bit which means more Hunt than Pacheco in a pass happy script along with a few shots to Thornton down the field with Worthy appearing to be OUT.

TAIL OR FADE + code “MAYO” at underdog for a deposit bonus up to $1000

WEEK 2 DRAFTKINGS OWNERSHIP PROJECTIONS

Tambo was FIRED, so he’s off the show for Week 2 (or he’s at a wedding and will be back next week. Who can say???) Erik Beimfohr stepped in for Tambo joining John and I for the DraftKings lineup building show. REMINDER: It’s LIVE each week at 10am ET.

We talked through injuries, values, traps, and built cores for each game as a starting point for your lineups.