Los Angeles Rams wide receiver Cooper Kupp suffered a high ankle sprain in Sunday's loss to the Arizona Cardinals and the injury will require surgery, head coach Sean McVay announced on Tuesday.

Related players: Tyler Higbee, Allen Robinson, Van Jefferson, Ben Skowronek

Kupp will be having tightrope surgery on Wednesday and the All-Pro WR will be placed on injured reserve, holding him out for at least four games, McVay added according to the story. While it's possible Kupp could return to this season, according to several other sources, with the Rams season fading fast there may be no reason to do that. It's a big loss for fantasy owners who were still getting fantasy production despite the Rams struggles on offense. TE Higbee could see a nice bump in production while at WR, Robinson, Jefferson and Skowronek could also see increases. It's a big hit for the already-struggling QB Matthew Stafford.

Rams HC Sean McVay told the media Monday that TE Tyler Higbee (MCL sprain) is day-to-day and will not practice to start this week.

Related Player: Kendall Blanton

Zero surprise regarding Higbee's status. His potential absence would open the door for Kendall Blanton and create a way to save salary in DFS.

Rams HC Sean McVay told reporters that the only injury status that concerns him heading into Super Bowl week is that of TE Tyler Higbee (MCL). RB Cam Akers has not practiced this week, but it was planned.

Related Player: Kendall Blanton

If Higbee does not play, Kendall Blanton becomes the salary relief play on the Rams side for DFS. It is also somewhat reassuring to see McVay open and honest about injuries heading into the season finale.

Rams TE Tyler Higbee has been activated from the reserve/COVID-19 list.

Higbee's return is welcomed since the tight end position has been a zero without him. It is unknown how the virus will alter his play and snap count Week 16 at Minnesota.

Rams’ RT Rob Havenstein, TE Tyler Higbee and SS Jordan Fuller were the three LA starters that did not test out to be able to play tonight vs. Seahawks, per source. They’re out tonight.

Related players: Kendall Blanton

With Higbee out in Week 14, Blanton filled in and caught two balls for 29 yards on three targets. If you waited to use Higbee, Blanton is at least a desperation play.

Rams placed CB Jalen Ramsey and TE Tyler Higbee on the Reserve/COVID-19 list. Both players out of tonight’s game vs. Cardinals.

Related players: Kendall Blanton, Jacob Harris

Two big losses in what is a key game for the NFC West. With Higbee out, Blanton and Harris are next up on the depth chart. Higbee had a 5-48-0 line last week against the Jags while Blanton caught one pass for six yards.

Rams TE Tyler Higbee is questionable to play Sunday against the San Francisco 49ers, according to head coach Sean McVay.

Gerald Everett would get a healthy amount of targets without Higbee in the lineup against a battered 49ers defense.

Rams TE Tyler Higbee is questionable to play Sunday against the Miami Dolphins, according to Lindsey Thiry of ESPN.

Related Player: Gerald Everett

Higbee has been a fantasy disappointment in 2020 and could lose more ground on teammate Gerald Everett if he misses a second straight game.