Isaac Guerendo
  • Isaac Guerendo

  • RB
  • , San Francisco 49ers
  • 25
  • 221 lbs
  • 6' 0"
  • Louisville
PtsRuYdsRuTDRecRecYds
79420415152
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Draft note
by John Paulsen
With Jordan Mason traded and Christian McCaffrey looking healthy heading into the season, Guerendo enters 2025 as one of the top handcuff running backs in fantasy football, provided he can hold off fifth-round rookie Jordan James for the RB2 job in San Francisco. Guerendo showed plenty of juice when given the opportunity last year, turning in 75, 102, 99, and 128 total yards in the four games where he played at least 50% of the snaps. He also ripped off 99 yards on just 10 carries in a limited role (26% of snaps) against Seattle in Week 6. He was also efficient as a receiver, posting 1.42 yards per route run—good for the 81st percentile among running backs—which bodes well for his three-down potential if pressed into service. McCaffrey has missed 20 games over the last three seasons, so the path to touches is clearer than it might seem on paper. Pending the camp battle with James, Guerendo is an elite handcuff and a perfect Zero RB target with league-winning upside if McCaffrey were to miss time.

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Isaac Guerendo

Scouting report

by Bill Riccette

SF RB Isaac Guerendo - Week 14 Fantasy Football Outlook

Week 14 vs. Chicago Bears

It's now Isaac Guerendo's backfield in San Francisco after both Christian McCaffrey and Jordan Mason were injured in Buffalo last week. Guerendo has averaged 4.7 yards per carry this season and does have a 99-yard outing back in Week 6 against the Seahawks. Guerendo is certainly worth looking at this week in a favorable matchup against the Bears, who rank 25th against the run and are allowing almost five yards per carry. Guerendo has RB2 upside this week.

2025 Strength of Schedule - SF

W1W2W3W4W5W6W7W8W9W10W11W12W13W14W15W16W17W18
15
@SEA
30
@NO
22
ARI
31
JAX
11
@LAR
4
@TB
9
ATL
6
@HOU
28
@NYG
11
LAR
22
@ARI
32
CAR
7
@CLE
BYE26
TEN
23
@IND
25
CHI
15
SEA

Schedule difficulty based on schedule-adjusted, positional defensive ranking. Top DEF = 1, bottom DEF = 32.

Game Stats

WeekOppRuAttRuYdsRuTDFumYPCRecRecYdsRecTDTgtsYPRSTD0.5 PPRPPRSnaps%
1NYJ00000.0000000.000.0-0.03/724.2%
2@MIN10000.0000000.000.0-0.01/701.4%
3@LAR519003.8000000.001.91.901.910/7114.1%
4NE10010.0000000.00-2.0-2.00-2.05/637.9%
5ARI522004.4000000.002.22.202.29/6414.1%
6@SEA1099009.9000000.009.99.909.917/6526.2%
7KC12002.0015015.000.71.201.75/637.9%
8DAL1485106.07317045.6716.217.7019.243/6863.2%
9BYE---------------
10@TB10000.0000000.000.0-0.03/644.7%
11SEA00000.0000000.000.0-0.02/633.2%
12@GB00000.0000000.000.0-0.00/490.0%
13@BUF419104.751-301-3.007.68.108.611/4822.9%
14CHI1578205.202500225.0024.825.8026.834/6155.7%
15LAR1657003.56418044.507.59.5011.541/5475.9%
16
@MIA---------------
17DET934003.784650416.259.911.9013.939/6460.9%
18@ARI25002.5000000.000.50.500.54/765.3%
Per game5.6028.000.270.075.001.0010.1301.0710.135.285.786.2815.13/64.4024.51%
Totals84420415.001515201610.1379.286.794.2227/101524.51%