Ke'Shawn Vaughn

In Week 15, the red and gold have defensive lineman Nick Bosa and linebacker Dre Greenlaw active and ready for the team's second meeting with their NFC West rival, the Los Angeles Rams.

On the other side of the ball, the 49ers will have rookie running back Isaac Guerendo available against the Rams. He was listed as questionable on Wednesday on account of a foot sprain but was given the green light to play ahead of "Thursday Night Football."

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We do expect Guerendo to handle the majority workload for TNF, but you do have to wonder if he gets the same type of workload he would have, had he avoided the injury report all week. Consider him closer to an RB3 than a locked-in RB2 he otherwise would have been.