Brock Purdy (toe), Ricky Pearsall (knee) and Jauan Jennings (ankle, ribs) are OUT for Thursday’s 49ers-Rams game.

Related Players: Mac Jones, Christian McCaffrey, Kendrick Bourne, Demarcus Robinson, Jake Tonges

Sheesh. With the lack of firepower, Jones should be more of a desperation streamer if your waiver wire is barren. Bourne and Robinson can probably be left off of lineups as well.

Christian McCaffrey seemed unbothered by the calf issue that crept up Thursday, and he did not appear on Shanahan’s Monday afternoon injury report.

Related players: Brian Robinson

The story went on to say that despite CMC's 31 touches, the 49ers at least made an effort to give him more breaks than normal. He played 76% of the offensive snaps. By comparison, he played 85% of the snaps in the 2023 opener in Pittsburgh, and that was a blowout win, the story went on to say. Robinson carried nine times for 33 yards. With all the injuries piling up, it's easy to see CMC continuing this pace, especially if he really did escape from Week 1 healthy.

49ers RB Christian McCaffrey is officially active for Sunday against the Seahawks.

Signs were pointing towards this being the case with McCaffrey reportedly good to go this weekend and being a big part of Saturday’s walkthrough. He’s good to go for your lineups.

49ers RB Christian McCaffrey is listed as questionable for Sunday’s game against the Seahawks but signs are pointing towards him playing.

It’s certainly understandably frustrating that we’re already talking about injuries again with McCaffrey but it’s better than his calf injury that cost him half the season in 2024. Barring a setback, it looks like McCaffrey will be out there.

The 49ers gave themselves some insurance with the acquisition of Brian Robinson from the Commanders and Isaac Guerendo is still in the mix. But if healthy, CMC still provides a ton of upside heading into Week 1. 49ers-Seahawks kicks off at 4:05.

49ers RB Christian McCaffrey (calf) is officially questionable for Sunday's opener against Seattle.

What's Kyle Shanahan's level of concern about Sunday? "Questionable concern. I'm not going to say anything about Christian, guys." Says it happened yesterday.

Related Players: Brian Robinson

This is quite ominous considering how last season went, but a lot of people are reporting this is more cautious than a serious injury. We should still consider McCaffrey a fantasy RB1 if he's on the field, with Robinson closer to the RB4 range.

49ers are listing RB Christian McCaffrey as limited at today’s practice due to a calf issue.

Related Players: Brian Robinson, Isaac Guerendo

It feels like we should panic, but players are limited in practice all the time (right?). We'll keep an eye on things but Robinson should be in our queues to plug in as an RB2 in case CMC is sidelined.

49ers placed WR Brandon Aiyuk and S​ Malik Mustapha on the Physically Unable to Perform List.

Related players: Jauan Jennings, Ricky Pearsall, Demarcus Robinson, Jacob Cowing, Skyy Moore, George Kittle, Christian McCaffrey

This news comes as no surprise. Aiyuk's timeline to return is around Week 6 as we previously reported. Jennings is dealing with a calf injury/contract issue, which means the Niners are without their top-two WRs, at the moment. Pearsall, Kittle and McCaffrey should carry the load in the passing game at least to start the season.

Kyle Shanahan was firm about Brian Robinson's expected role after San Francisco sent a 2026 sixth-round pick to the Washington Commanders for him last week.

"We brought him here to be our [No.] 2 back," Shanahan said. "I've always been a big fan of Brian. Loved him coming out of college. ... We were pumped that he was available and pumped that we were able to get him."

In 2024, Robinson was third in the league on a third or fourth down of 3 or fewer yards (7.8 yards per carry), though the sample size was just 14 attempts.
Christian McCaffrey will remain the focal point of San Francisco's running game, but Robinson provides an experienced backup who could offer some value in short-yardage situations.

Related players: Isaac Guerendo

The story said the 49ers were 18th in the league in short-yardage situations, averaging 3.2 yards per rush. The story went on to say Guerendo has struggled to stay healthy. Though he just got back from a shoulder injury, he had a pair of fumbles in a recent practice and is more likely to have an early-season spot on various special teams units.

Trade: Commanders are trading RB Brian Robinson to the 49ers in exchange for a 2026 sixth-round pick, sources tell ESPN.

Related Players: Austin Ekeler, Jacory Crosky-Merritt, Christian McCaffrey, Isaac Guerendo

This is awful news for Guerendo drafters, but with all the injuries to the 49ers' running back room, they needed a dependable body in the room. This dings McCaffrey a little bit, but his passing-game involvement should be enough to secure another top-10 (or higher finish), while Robinson will pick up most of the slack and deliver as a FLEX play in tough weeks.

Back in Washington, Crosky-Merritt should be boosted out of low-end RB4 territory into an RB3 while Ekeler has some sneaky upside to finish in the same range.

RB Isaac Guerendo returned to practice and had an active day. So as Patrick Taylor and Corey Kiner exit due to injuries, Guerendo comes back.

Related players: Christian McCaffrey, Jordan James, Jeff Wilson

It's always news when a potential CMC handcuff is back on the field. Guerendo missed time with a shoulder injury and the rookie James is still out, so Guerendo could secure his RB2 role behind McCaffrey, who has looked good and close to his 2023 form so far in camp, according to reports. Still, those owning CMC likely want to have protection - just in case. Guerendo proved he can do the job last season.