49ers are listing RB Christian McCaffrey as limited at today’s practice due to a calf issue.

Related Players: Brian Robinson, Isaac Guerendo

It feels like we should panic, but players are limited in practice all the time (right?). We'll keep an eye on things but Robinson should be in our queues to plug in as an RB2 in case CMC is sidelined.

Kyle Shanahan was firm about Brian Robinson's expected role after San Francisco sent a 2026 sixth-round pick to the Washington Commanders for him last week.

"We brought him here to be our [No.] 2 back," Shanahan said. "I've always been a big fan of Brian. Loved him coming out of college. ... We were pumped that he was available and pumped that we were able to get him."

In 2024, Robinson was third in the league on a third or fourth down of 3 or fewer yards (7.8 yards per carry), though the sample size was just 14 attempts.
Christian McCaffrey will remain the focal point of San Francisco's running game, but Robinson provides an experienced backup who could offer some value in short-yardage situations.

Related players: Isaac Guerendo

The story said the 49ers were 18th in the league in short-yardage situations, averaging 3.2 yards per rush. The story went on to say Guerendo has struggled to stay healthy. Though he just got back from a shoulder injury, he had a pair of fumbles in a recent practice and is more likely to have an early-season spot on various special teams units.

Trade: Commanders are trading RB Brian Robinson to the 49ers in exchange for a 2026 sixth-round pick, sources tell ESPN.

Related Players: Austin Ekeler, Jacory Crosky-Merritt, Christian McCaffrey, Isaac Guerendo

This is awful news for Guerendo drafters, but with all the injuries to the 49ers' running back room, they needed a dependable body in the room. This dings McCaffrey a little bit, but his passing-game involvement should be enough to secure another top-10 (or higher finish), while Robinson will pick up most of the slack and deliver as a FLEX play in tough weeks.

Back in Washington, Crosky-Merritt should be boosted out of low-end RB4 territory into an RB3 while Ekeler has some sneaky upside to finish in the same range.

RB Isaac Guerendo returned to practice and had an active day. So as Patrick Taylor and Corey Kiner exit due to injuries, Guerendo comes back.

Related players: Christian McCaffrey, Jordan James, Jeff Wilson

It's always news when a potential CMC handcuff is back on the field. Guerendo missed time with a shoulder injury and the rookie James is still out, so Guerendo could secure his RB2 role behind McCaffrey, who has looked good and close to his 2023 form so far in camp, according to reports. Still, those owning CMC likely want to have protection - just in case. Guerendo proved he can do the job last season.

49ers rookie RB Jordan James broke his finger and is getting surgery. Will be out "a couple weeks", Shanahan said

Related Players: Christian McCaffrey, Isaac Guerendo, Corey Kiner, Ameer Abdullah

Guerendo is already sidelined with a shoulder injury so things are pretty thin in the RB room right now. If CMC wasn't already slated for a giant workload, that looks just about locked in at this point. He's an easy first-round click.

49ers RB Isaac Guerendo is expected to miss “a few weeks” with a shoulder injury, per Kyle Shanahan.

Related players: Christian McCaffrey, Jordan James, Patrick Taylor

With Guerendo missing that much time, it could open the door for the rookie James, who has already looked good in camp, according to those who follow the team. Guerendo certainly did enough last year as a rookie to still be in the mix. The 49ers are a CMC injury away from having someone else step in and get an RB1 workload, so fantasy owners will want to keep an eye on the team's RB2 battle in camp.

Shanahan said Isaac Guerendo (hamstring) was trending well and is expected to practice this week.

Related players: Patrick Taylor, Deebo Samuel

The Niners play on Monday night at home against the Lions. So those waiting on Guerendo may want to have a backup plan. Hopefully owners will get more information about his status well before that. He should be in line for a big workload, if he plays, just given his draft capital and past usage as the team's now RB1. Samuel would likely get some carries as well.

49ers injury report vs. Dolphins:
Out
RB Isaac Guerendo (foot, hamstring)
OT Trent Williams (ankle)
Questionable
DE Nick Bosa (hip, oblique)
LB Dre Greenlaw (Achilles, knee)
DE Robert Beal (ankle)
(Approximately, 70% of the players the 49ers listed as questionable have played.)

Related Players: Patrick Taylor, Kyle Juszczyk, Israel Abanikanda

We're assuming Taylor will now be the next, next man up, but they also have Abanikanda, as well as Ke'Shawn Vaughn on the practice squad. Taylor should be considered somewhere in the RB3 range if Guerendo is out, but the others should just be on WW watch for now.

After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday’s game vs. Miami. Guerendo is dealing with a hamstring injury and is unlikely to play, per source.

Related Players: Patrick Taylor, Kyle Juszczyk, Israel Abanikanda

Sheesh. We're assuming Taylor will now be the next, next man up, but they also have Abanikanda, as well as Ke'Shawn Vaughn on the practice squad. Taylor should be considered somewhere in the RB3 range if Guerendo is out.

In Week 15, the red and gold have defensive lineman Nick Bosa and linebacker Dre Greenlaw active and ready for the team's second meeting with their NFC West rival, the Los Angeles Rams.

On the other side of the ball, the 49ers will have rookie running back Isaac Guerendo available against the Rams. He was listed as questionable on Wednesday on account of a foot sprain but was given the green light to play ahead of "Thursday Night Football."

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We do expect Guerendo to handle the majority workload for TNF, but you do have to wonder if he gets the same type of workload he would have, had he avoided the injury report all week. Consider him closer to an RB3 than a locked-in RB2 he otherwise would have been.