San Francisco 49ers running back Isaac Guerendo plans to play Thursday night against the Los Angeles Rams despite his sprained foot, sources told ESPN's Adam Schefter.

Guerendo, who is listed as questionable, insists he "feels good," sources said.

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We're projecting Patrick Taylor as the next man up in the 49ers' version of running back roulette *if* Guerendo is forced out, as he easily has the most familiarity with the team. Abanikanda can be stashed if that's not the case, but shouldn't be in starting consideration if Guerendo does indeed miss Week 15.

Otherwise, consider the fourth-round rookie a fantasy RB2.

— The 49ers ruled out LT Trent Williams (ankle) and S Malik Mustapha (chest), but RB Isaac Guerendo (foot) is questionable. So is Dre Greenlaw, who was full today.
— The Rams ruled out TE Tyler Higbee (knee) and Cobie Durant (chest).

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We're projecting Patrick Taylor as the next man up in the 49ers' version of running back roulette, as he easily has the most familiarity with the team. Abanikanda can be stashed if that's not the case, but shouldn't be in starting consideration if Guerendo does indeed miss Week 15.

49ers head coach Kyle Shanahan shared his team’s pre-practice injury report at a Tuesday press conference and it was the same as Monday’s estimated one, so several key players are on the sideline ahead of Thursday’s game against the Rams.

Among them was RB Isaac Guerendo.

Related players: Patrick Taylor, Israel Abanikanda

Guerendo had a great game in Week 14, but left with a sprained foot. Guerendo said afterward he felt great and it was just precautionary. However, we know by now we can't always trust when a player talks about his status for the following week. The DNPs for both Monday and Tuesday are not a great sign for Guerendo's chances to play in Week 15, which is a short week against the Rams on Thursday Night Football. Guerendo's practice status for Wednesday will hopefully will give us a better idea. Taylor would likely be next up for the 49ers if Guerendo can't go.

Isaac Guerendo doesn't seem concerned about the foot sprain he suffered today.

Related players: Patrick Taylor, Israel Abanikanda

Guerendo was having a great fantasy day and was the team's clear RB1 against the Bears before leaving with a foot sprain. There are a couple of reports out there, including this one which comes from the Mercury News, saying Guerendo leaving was just precautionary, and that he "feels great." Other reports don't necessarily mention that. Hopefully we'll learn more today. What complicates this injury is the Niners take on the Rams on Thursday night, so it's a short week. We'll at least learn more as the practice week goes on. If Guerendo can 't go, Taylor is up next with newly-signed Abanikanda after that.

The 49ers were down to one healthy running back on their active roster, so they added another one off the waiver wire on Tuesday.

The NFL’s daily transaction report shows that they have claimed Israel Abanikanda off of waivers from the Jets. Abanikanda was let go on Monday when the Jets signed running back/kick returner Kene Nwangwu to the 53-man roster.

Christian McCaffrey was officially moved to injured reserve in a corresponding move.

Related players: Isaac Guerendo, Patrick Taylor, Ke'Shawn Vaughn

Guerendo is expected to take over the team's RB1 role with Christian McCaffrey and Jordan Mason both heading to IR. Abanikanda should be a familiar name to those in dynasty circles. He was a 2023 fifth-round pick but at the time was buried on the depth chart with the Jets, and he never earned much of a role on offense and didn’t play in the regular season this year, the story said. He appeared in six games as a rookie and ran 22 times for 70 yards while catching seven passes for 43 yards, the story added. The team also signed Vaughn to their practice squad.

Per Kyle Shanahan, 49ers RB Christian McCaffrey us going back on IR with his PCL injury.

Related players: Isaac Guerendo, Deebo Samuel, Jordan Mason

It’s a 6 week recovery time for CMC, the post went on to say. It's possible he could return if the Niners make a long playoff run, but for this fantasy season, McCaffrey is done. Sandler, in a separate post, mentioned that Mason will also go on IR with a high ankle sprain, leaving Guerendo as the assumed RB1. The Niners will have to make a move to bring in more running backs, but the team did trade up in the fourth round to pick Guerendo, so it's possible they give him a legit chance the rest of the season. He should be a popular pickup off the wire this week.

49ers RB Christian McCaffrey was limited in practice today, but HC Kyle Shanahan said he has had “no pain”, an encouraging sign for his availability Sunday.

Related Players: Jordan Mason, Kyle Juszczyk, Isaac Guerendo

If the 49ers had a commanding lead in the NFC West, there's a pretty good chance they would be more willing to ease CMC back into the gameplan, but at 4-4, they are not really in a position to mess around here. If McCaffrey is good to go, we should consider him an RB1 in Week 10.

Ian Rapoport is reporting the 49ers are still targeting Week 10 for RB Christian McCaffrey's return.

Related players: Jordan Mason, Isaac Guerendo

The Niners have a bye in Week 9 and we reported last week it was looking positive for CMC to return to the field for Week 10, which is an early Sunday game at the Buccaneers. Rapoport has said CMC has been ramping up and so far there have been no setbacks, and that continues to be a target date. It's possible CMC is heavily involved in the pass game with all the injuries to the Niners WRs up to this point.

RB Jordan Mason (shoulder) was in a blue jersey, I'm told.

Related players: Isaac Guerendo, Patrick Taylor, Kyle Juszczyk

Reports said Mason's injury wasn't considered too serious, and it's a good sign he was back at practice, despite wearing the non-contact jersey. The Niners will host the Chiefs and what should be a fun game to watch in the later window of Sunday. If Mason can't go, look for Guerendo to pick up the slack after he carried 10 times for 99 yards in Week 6 after Mason left the game.

The NFL’s leading rusher, 49ers RB Jordan Mason, is believed to have suffered a sprained AC joint during Thursday night’s win at Seattle that is not considered serious, but he will undergo further testing today, per sources.

Related Players: Isaac Guerendo, Patrick Taylor

This doesn't give us a good lean on how much time he could miss (if any), but there's a good chance Guerendo gets a shot at leading the rushing attack after he put the game away with a 70+ yard run. We'll keep an eye on the situation, but hopefully, Mason isn't forced to miss too much time.