Breida has made a season out of playing hurt, so it seems he at least has a shot of suiting up. If he does, it would kill Jeff Wilson's value, but we wouldn't be surprised if Wilson cuts into Breida's workload somewhat. Look at Breida as a flex option and not much more.
With Pierre Garcon out and Marquise Goodwin also questionable, the 49ers need Pettis to be active. Deeper league owners would like it, too, as he has been quite productive over the last three weeks totaling 12 receptions, 255 yards and four scores. He is worth starting as a WR3.