Only two 49ers I did not see participating during early open portion of Thursday’s practice: WRs Deebo Samuel and Jauan Jennings. Jennings was doing some work on the side. WR Brandon Aiyuk is out of blue no contact jersey. LB Dre Greenlaw also back in the mix.

Related Players: Ronnie Bell, Ray-Ray McCloud

In addition to Bell and McCloud, Tay Martin, Chris Conley and Isaiah Winstead are options the team could pull from their practice squad. We'll keep an eye on all of these injuries heading into Friday's practice, but we could be looking at a very run-heavy approach from the 49ers as 14-point favorites on Sunday.

49ers’ WR Brandon Aiyuk, listed as questionable for tonight’s game due to a shoulder injury, is not expected to play vs. the Giants.

Related Players: Deebo Samuel, Jauan Jennings, Ronnie Bell

The 49ers rarely have their "Big Four" all on the field simultaneously, which is a shame because it's such a fun offense to watch when it's rolling. We can expect a slight uptick in target share for both George Kittle and Deebo Samuel, while it's also likely Christian McCaffrey will get a little more action as a receiver. Though Jauan Jennings had a couple of big plays in the team's Week 2 victory, it's not enough to consider him in fantasy outside of DFS Showdown slates.

Brandon Aiyuk (shoulder) will be, as expected, a game-time decision for 49ers-Giants on TNF, per John Lynch on KNBR

Related Players: Deebo Samuel, Jauan Jennings, Ronnie Bell

The 49ers rarely have their "Big Four" all on the field simultaneously, which is a shame because it's such a fun offense to watch when it's rolling. We can expect a slight uptick in target share for both George Kittle and Deebo Samuel, while it's also likely Christian McCaffrey will get a little more action as a receiver. Though Jauan Jennings had a couple of big plays in the team's Week 2 victory, it's not enough to consider him in fantasy outside of DFS Showdown slates.

Update from the 49ers: Deebo Samuel has a MCL sprain and an ankle sprain and he's expected to return at some point during the regular season.

Related Players: Jordan Mason, Brandon Aiyuk, George Kittle, Jauan Jennings, Ray-Ray McCloud

This is a bummer for the team and fantasy purposes, as this impacts the playoff implications for both facets. If you don't have an IR spot, it may be a waste of a spot for Deebo if he isn't going to return before Week 17.

Deebo Samuel (hamstring) was limited for the second straight practice

Related Players: Brandon Aiyuk, George Kittle, Jauan Jennings

If Deebo were to miss, it's possible that there's a little more touchdown equity for the receiving corps as well as Christian McCaffrey and Elijah Mitchell. Samuel hasn't been used as often in the run game as he was in 2021, but he does have two rushing TDs on the season.

FULL 49ers' injury summary:

No practice:
Arik Armstead (foot/ankle)
Samson Ebukam (quad/Achilles)

Limited:
Jason Verrett (knee)
Dre Greenlaw (calf)

Full:
Deebo Samuel
Jauan Jennings
Kyle Juszczyk
Colton McKivitz*
Azeez Al-Shaair*
Elijah Mitchell*

*No official designation (IR)

Good news for Deebo owners. Samuel missed Week 8 with a hamstring injury which led up to the team's bye in Week 9. The extra rest seems to have helped, and it appears Samuel should be good to go in Week 10.

Not practicing today for the 49ers:
* Deebo Samuel (hamstring)
* Kyle Juszczyk (finger)
* Dre Greenlaw (calf)
* Arik Armstead (foot/ankle)
* Jauan Jennings (hamstring)
* Samson Ebukam (Achilles tendinitis)

The Niners have a bye in Week 9 so Samuel's status is worth monitoring in case the team decides to rest him for a couple of weeks.

49ers WR Deebo Samuel (groin) and RB Trey Sermon (ankle) will not play Week 13 at Seattle.

Related Players: Trenton Cannon, Jeff Wilson, Jauan Jennings, Trent Sherfield

Nothing changes from their expected statuses earlier this week.