Squirrel’s Nuts & Bolts: Seahawks - Cardinals Showdown Strategy (Week 4 NFL DFS)

Sep 25, 2025

Steven Bisig-Imagn Images

Week 4 of the NFL season kicks off with an NFC West showdown as the Seahawks visit the Cardinals in Arizona. Both teams enter at 2–1 in a division where every club is over .500, and the four teams have combined for nine wins – no other division has more than seven wins. Seattle is a 1.5-point road favorite with a game total of 43.5, reflecting two tough defenses: the Seahawks have allowed the second-fewest points in the league, the Cardinals the fifth-fewest.

Both teams have concentrated offenses and injury questions at the RB position. Seattle features Jaxon Smith-Njigba, the NFL’s current target-share leader, who has drawn 29 of the team’s 72 targets (40.3%) and turned them into 22 catches for 323 yards, second-most in the league. In the running game, Zach Charbonnet logged two more carries than Kenneth Walker III in Weeks 1 and 2 before missing Week 3 with a foot injury. Walker scored twice last week but managed just 38 yards on 16 carries. Cooper Kupp and Tory Horton round out the main receiving threats for quarterback Sam Darnold.

Arizona features a similarly concentrated offense behind QB Kyler Murray. TE Trey McBride owns a 27.3% target share (24 of 88 targets), tops among NFL TEs and good enough to rank 13th among wideouts. After James Conner’s season-ending leg injury last week, rookie Trey Benson – considered one of the NFL’s better young backups – takes over as Arizona’s primary runner. He already tops the team with 125 rushing yards and eight receptions for 45 yards. Marvin Harrison Jr., Michael Wilson, and Greg Dortch offer supporting options in the passing game for Arizona. Harrison may draw more DFS attention than warranted because of his draft pedigree, but I’ll stay under the field until he shows more of it.