Wilson was pulled down awkwardly while being sacked by San Francisco's Eli Harold with 10 minutes to go in the third quarter. Harold was flagged for a horse collar tackle on the play as he fell on Wilson's lower leg. Wilson stayed down for a few moments before hoping up and limping around. He missed one play on that series - the first missed play of his career due to injury - but returned to throw one more pass, a 10-yard completion to Doug Baldwin.
Wilson was on the Seattle bench for its next offensive possession having a brace put on his left knee after a San Francisco turnover led to a quick change of possession. Trevone Boykin took over and Steven Hauschka's third field goal gave Seattle a 30-3 lead.
The knee injury comes on top of Wilson playing the last two weeks after suffering a sprained right ankle in the opener against Miami. Wilson was said to have more mobility coming into this week with the ankle, but the knee injury at least puts in question his status for the Seahawks next game.