49ers injury report vs. Dolphins:
Out
RB Isaac Guerendo (foot, hamstring)
OT Trent Williams (ankle)
Questionable
DE Nick Bosa (hip, oblique)
LB Dre Greenlaw (Achilles, knee)
DE Robert Beal (ankle)
(Approximately, 70% of the players the 49ers listed as questionable have played.)

Related Players: Patrick Taylor, Kyle Juszczyk, Israel Abanikanda

We're assuming Taylor will now be the next, next man up, but they also have Abanikanda, as well as Ke'Shawn Vaughn on the practice squad. Taylor should be considered somewhere in the RB3 range if Guerendo is out, but the others should just be on WW watch for now.

After losing RBs Christian McCaffrey, Jordan Mason and Elijah Mitchell to season-ending injuries, it now looks as if the 49ers will be without RB Isaac Guerendo for Sunday’s game vs. Miami. Guerendo is dealing with a hamstring injury and is unlikely to play, per source.

Related Players: Patrick Taylor, Kyle Juszczyk, Israel Abanikanda

Sheesh. We're assuming Taylor will now be the next, next man up, but they also have Abanikanda, as well as Ke'Shawn Vaughn on the practice squad. Taylor should be considered somewhere in the RB3 range if Guerendo is out.

In Week 15, the red and gold have defensive lineman Nick Bosa and linebacker Dre Greenlaw active and ready for the team's second meeting with their NFC West rival, the Los Angeles Rams.

On the other side of the ball, the 49ers will have rookie running back Isaac Guerendo available against the Rams. He was listed as questionable on Wednesday on account of a foot sprain but was given the green light to play ahead of "Thursday Night Football."

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We do expect Guerendo to handle the majority workload for TNF, but you do have to wonder if he gets the same type of workload he would have, had he avoided the injury report all week. Consider him closer to an RB3 than a locked-in RB2 he otherwise would have been.

San Francisco 49ers running back Isaac Guerendo plans to play Thursday night against the Los Angeles Rams despite his sprained foot, sources told ESPN's Adam Schefter.

Guerendo, who is listed as questionable, insists he "feels good," sources said.

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We're projecting Patrick Taylor as the next man up in the 49ers' version of running back roulette *if* Guerendo is forced out, as he easily has the most familiarity with the team. Abanikanda can be stashed if that's not the case, but shouldn't be in starting consideration if Guerendo does indeed miss Week 15.

Otherwise, consider the fourth-round rookie a fantasy RB2.

— The 49ers ruled out LT Trent Williams (ankle) and S Malik Mustapha (chest), but RB Isaac Guerendo (foot) is questionable. So is Dre Greenlaw, who was full today.
— The Rams ruled out TE Tyler Higbee (knee) and Cobie Durant (chest).

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We're projecting Patrick Taylor as the next man up in the 49ers' version of running back roulette, as he easily has the most familiarity with the team. Abanikanda can be stashed if that's not the case, but shouldn't be in starting consideration if Guerendo does indeed miss Week 15.

49ers RB Christian McCaffrey was limited in practice today, but HC Kyle Shanahan said he has had “no pain”, an encouraging sign for his availability Sunday.

Related Players: Jordan Mason, Kyle Juszczyk, Isaac Guerendo

If the 49ers had a commanding lead in the NFC West, there's a pretty good chance they would be more willing to ease CMC back into the gameplan, but at 4-4, they are not really in a position to mess around here. If McCaffrey is good to go, we should consider him an RB1 in Week 10.

RB Jordan Mason (shoulder) was in a blue jersey, I'm told.

Related players: Isaac Guerendo, Patrick Taylor, Kyle Juszczyk

Reports said Mason's injury wasn't considered too serious, and it's a good sign he was back at practice, despite wearing the non-contact jersey. The Niners will host the Chiefs and what should be a fun game to watch in the later window of Sunday. If Mason can't go, look for Guerendo to pick up the slack after he carried 10 times for 99 yards in Week 6 after Mason left the game.

FULL 49ers' injury summary:

No practice:
Arik Armstead (foot/ankle)
Samson Ebukam (quad/Achilles)

Limited:
Jason Verrett (knee)
Dre Greenlaw (calf)

Full:
Deebo Samuel
Jauan Jennings
Kyle Juszczyk
Colton McKivitz*
Azeez Al-Shaair*
Elijah Mitchell*

*No official designation (IR)

Good news for Deebo owners. Samuel missed Week 8 with a hamstring injury which led up to the team's bye in Week 9. The extra rest seems to have helped, and it appears Samuel should be good to go in Week 10.

Not practicing today for the 49ers:
* Deebo Samuel (hamstring)
* Kyle Juszczyk (finger)
* Dre Greenlaw (calf)
* Arik Armstead (foot/ankle)
* Jauan Jennings (hamstring)
* Samson Ebukam (Achilles tendinitis)

The Niners have a bye in Week 9 so Samuel's status is worth monitoring in case the team decides to rest him for a couple of weeks.