49ers WR Mario Manningham (knee, probable) returned to ...

Tyjae Spears did not practice Thursday after participating on a limited basis Wednesday because of a knee injury. Tony Pollard returned to full participation after receiving a rest day Wednesday.

Related Players: Julius Chestnut, Cam Ward

Spears’ downgrade puts his PPR FLEX availability in doubt. If he misses Sunday, Pollard would become a stronger RB2 play with a chance to absorb additional receiving work alongside his rushing workload. Chestnut will likely see a handful or two of snaps, but with the Titans' general offensive infrastructure, you should be able to find better options on your waiver wire.

No Jeremiyah Love at #AZCardinals practice again today.

Related Players: Tyler Allgeier, Zonovan Knight, Jacoby Brissett

Allgeier should be added where available. If Love misses Sunday, Allgeier would have a clear path from FLEX territory into RB2 consideration as Arizona’s lead runner. Knight would become a deeper-league bench option behind him, but that is more in the "desperation" zone than recommended.

San Francisco on Thursday announced veteran wide receiver Christian Kirk is returning to practice.

Wide receiver Mike Evans was not scheduled to practice Thursday due to ribs and Achilles soreness, coach Kyle Shanahan said.

Related Players: Deebo Samuel, Brandin Cooks, Jordan Watkins, Jacob Cowing, George Kittle, Brock Purdy, Christian McCaffrey

Evans’ managers need a Monday-night replacement plan. If he misses the game, Cooks could move into boom-bust, WR3/FLEX consideration, with Watkins and Cowing becoming options for very deep leagues. Kittle and McCaffrey would remain premium starts, with additional receiving opportunities available.