Update from the 49ers: Deebo Samuel has a MCL sprain and an ankle sprain and he's expected to return at some point during the regular season.

Related Players: Jordan Mason, Brandon Aiyuk, George Kittle, Jauan Jennings, Ray-Ray McCloud

This is a bummer for the team and fantasy purposes, as this impacts the playoff implications for both facets. If you don't have an IR spot, it may be a waste of a spot for Deebo if he isn't going to return before Week 17.

Christian McCaffrey said he dodged a bullet with his knee issue, said he’ll play in full Sunday. “I feel great,” he said.

Related Players: Tyrion Davis-Price, Jordan Mason

If CMC is a full go, Davis-Price and Mason are obsolete as anything more than a desperation play. McCaffrey should be considered an RB1, even if he's banged up.

Who rises in the running back rotation now that Elijah Mitchell will miss a substantial amount of time? Never underestimate Shanahan’s fondness for veteran Tevin Coleman, who is on the practice squad but had a pivotal role in the Week 5 win in Carolina.

Meanwhile, Shanahan continues to sing the praises of third-round pick Tyrion Davis-Price even though Price has been a healthy scratch since Week 7. Jordan Mason has been in uniform instead of Davis-Price because Mason is the better special-teamer and has become a stalwart on the kickoff and punt units.

Related players: Christian McCaffrey

The story said McCaffrey played about 65% of the snaps but is also dealing with some knee irritation. Ideally, the 49ers would like to keep McCaffrey around that mark, so the RB who is next up could certainly have some fantasy value with Mitchell sidelined again. In deeper leagues or dynasty leagues, Coleman could still be on your wire and may be worth a stash until this situation sorts itself out.

The 49ers hoped to avoid a long-term knee injury with Elijah Mitchell. They didn't. Mitchell is expected to miss 6-8 weeks, per head coach Kyle Shanahan. Meanwhile, the 49ers will manage Christian McCaffrey's "knee irritation" during the week.

Related Players: Jordan Mason, Tyrion Davis-Price

The injury bug continues to live rent-free inside the 49ers backfield. Stay tuned for what exactly "knee irritation" means, but Tyrion Davis-Price should be nabbed off of waiver wires wherever he is available for the fantasy playoffs. Davis-Price is no longer going to be healthy-scratched and needs to be on all fantasy rosters moving forward in case he becomes the de facto RB1 in San Francisco's offense.

Head coach Kyle Shanahan said on Monday that third-round pick Tyrion Davis-Price is going to miss “a few weeks” after suffering a high-ankle sprain in Sunday’s win over the Seahawks.

Related players: Elijah Mitchell, Jeff Wilson, Kyle Juszczyk, Jordan Mason, Marlon Mack

The Niner RBs are falling fast as this comes after the team lost Mitchell for about 8 weeks, according to reports. With Wilson the lead back, Mason now becomes an injury away from possibly seeing a significant fantasy role. Juszczyk could continue to steal goal line TDs.

Rookie running back Tyrion Davis-Price is expected to miss "at least" a few weeks, according to 49ers head coach Kyle Shanahan.

Related Players: Jeff Wilson, Jordan Mason, Marlon Mack

TE Tyler Kroft also has an MCL sprain, to add insult to injury. Jeff Wilson had the majority control of the backfield in Week 2, turning his 20 touches into 103 yards from scrimmage, while Davis-Price and Deebo Samuel had their fair share of work in a lopsided 27-7 victory over the Seahawks. We will keep an eye on the situation as the week(s) progresses, but expect Deebo to continue working as a hybrid back while San Francisco continues to deal with a never-ending barrage of injuries at the position.

Ty Davis-Price or Jordan Mason? Kyle Shanahan said the two will compete in practice this week to see who will be the No. 2 runner behind Jeff Wilson on Sunday. "We'll go with the hot hand in the game."

Wilson might have to earn his playing time, despite being the starter and a popular waiver pick up this week. If one of Davis-Price or Mason steps up, it wouldn't be a shock to see Shanahan give them more work. Deebo Samuel will likely factor in the running game as well. Wilson is at least the guy this week but there may be some reason to worry about his long term fantasy value.

Jeff Wilson appeared in nine games last season after recovering from a torn meniscus in a knee. When he did play, he didn't look much like the player who led the team in rushing in 2020. Another year removed from that injury, Wilson appeared to be closer to his former self in training camp, though he managed just 22 yards on nine carries after replacing Mitchell at rain-soaked Soldier Field on Sunday.

"We've always been comfortable with Jeff, just because of his experience and what he has done here," Kyle Shanahan said. "We know what we're going to get."

Related players: Elijah Mitchell, Tyrion Davis-Price, Kyle Juszczyk, Jordan Mason, Marlon Mack, Deebo Samuel

What the Niners may not be comfortable with is what's behind Wilson at this point, though. Davis-Price is a rookie who was inactive in Week 1 behind undrafted rookie Mason. Mason played on special teams, however. The team signed Mack but he couldn't make the Texans roster. It's possible Samuel sees an uptick in rushes. The team seems like a Wilson injury away from a big problem at RB.

49ers are signing former Texans’ RB Marlon Mack to their practice squad, per source.

Related players: Jeff Wilson, Tyrion Davis-Price, Kyle Juszczyk, Jordan Mason

Wilson is expected to be the starter but Mack gives a little more security on the depth chart should he be needed as Davis-Price is a rookie.