49ers QB Brock Purdy is active, Bills WR Keon Coleman is inactive for Sunday Night Football.

Purdy was questionable but trended towards playing with a shoulder injury that caused him to miss last week. It will be interesting to see how the 49ers handle him, given the injury and the weather conditions.

Coleman was limited in practice all week with a wrist injury, so it seems the Bills are being cautious with their rookie.

Sean McDermott says Bills WR Keon Coleman will not play Sunday against Kansas City.

Related players: Khalil Shakir, Mack Hollins, Curtis Samuel

It was possible that Coleman was going to miss multiple weeks of action with the wrist injury and that's now already confirmed. It's the second-straight week Coleman will be out. The Bills are hoping to get back Cooper this week, but if they don't Shakir and Hollins will be the top WRs with Samuel likely also involved. Hollins had a 4-86-0 line with Shakir collecting a 6-58-0 line in Week 10 against the Colts.

Sean McDermott has ruled out wide receiver Keon Coleman on WGR550

Related Players: Amari Cooper, Khalil Shakir, Mack Hollins, Dalton Kincaid

Still no word on whether Amari Cooper will be playing, but we should see Shakir continue in his role that has seen him hit 7+ targets in three straight games. He's a WR2 in Week 10.

Second straight day with no practice for Keon Coleman.

Amari Cooper continues to be limited. Christian Benford fully participating is a good sign.

Related Players: Khalil Shakir, Mack Hollins, Dalton Kincaid

It seems as though Cooper is still dealing with his wrist issue as well, so the Bills might be right back to having an extremely thin WR room once again for Week 10. Consider Shakir a high-floor WR2 if either or both of his teammates miss.

Sean McDermott said that WR Keon Coleman won't practice on Wednesday and that it could be "more than just this week," but that they are still evaluating. He is not ruled out for this week's game vs. the Colts.

Related Players: Amari Cooper, Khalil Shakir, Mack Hollins, Dalton Kincaid

It seems as though Cooper is still dealing with an issue as well, so the Bills might be right be to having an extremely thin WR room once again for Week 10. Consider Shakir a high-floor WR2 if either or both of his teammates miss.

Bills rookie WR Keon Coleman will have tests done on his wrist today. Stay tuned.

Related players: Amari Cooper, Khalil Shakir, Curtis Samuel, Mack Hollins, Josh Allen

With Cooper missing Week 9, the Bills could find themselves even more short at WR as they enter Week 10, which is an early Sunday game at the Colts. If Coleman has to miss time, it should mean more targets for Shakir, Samuel and Hollins, depending on Cooper's status going forward.

Bills coach Sean McDermott said that LB Terrel Bernard should be good to go for Sunday's game.

WR Amari Cooper, WR Curtis Samuel and CB Christian Benford will be listed as questionable.

Related Players: Khalil Shakir, Keon Coleman, Mack Hollins, Dalton Kincaid

Cooper's second game in a Bills uniform was a bit of a letdown, considering his 4-66-1 stat line in limited action the week before. Shakir and Coleman are nice WR3 options this week, with a slight bump to their floors if Cooper were to miss.

Bills HC Sean McDermott said he doesn't think WR Curtis Samuel will need to go on IR, but he could miss more than just this week's game.

Related Players: Amari Cooper, Khalil Shakir, Keon Coleman, Dalton Kincaid

Samuel has been a non-factor on a team- and fantasy-level this season. It's possible his missing slot usage adds a small boost to Shakir and/or Kincaid.

According to multiple reports, the Bills are acquiring Amari Cooper from the Browns.

Buffalo will receive Cooper and a 2025 sixth-round pick while Cleveland will receive a 2025 third-round pick along with a 2026 seventh-round pick.

Related players: Josh Allen, Khalil Shakir, Keon Coleman, Curtis Samuel, Dalton Kincaid, Dawson Knox, Jerry Jeudy, Elijah Moore, Cedric Tillman, David Njoku

Cooper, 30, has caught 24 passes for 250 yards with two touchdowns this season. His fantasy production has been inconsistent so far, but that can probably be blamed on the poor play of quarterback Deshaun Watson. Last year Cooper finished with a line of 72-1,250-5, mostly without Watson under center. Cooper will eventually be locked in as the Bills WR1 and push players like Shakir, Coleman Kincaid and Knox further down the fantasy depth chart. It's easy to see Cooper having a chance to thrive with Allen as his QB. Meanwhile in Cleveland, Jeudy, Moore and Tillman will battle it out at the WR position with Njoku becoming more of a target at TE.

Sean McDermott says on WGR550 that DT Ed Oliver, WR Khalil Shakir, DT Austin Johnson, and S Taylor Rapp are OUT for Sunday’s game

Related Players: Mack Hollins, Curtis Samuel, Keon Coleman, Dalton Kincaid

The receiving room behind Shakir has been mostly miserable through the first month of the season, though the rookie Coleman has looked pretty good in his limited role. None of them are particularly exciting, though Coleman can be used as a desperation Flex in a game that should see him with a high route participation.

Kincaid becomes a top-5 option at the tight end position.