Squirrel Patrol's Week 7 NFL Main Slate DFS GPP Picks

Oct 23, 2026

IMAGN IMAGES via Reuters Connect

Week 7 brings a 10-game main slate on Sunday, kicking off at 1 PM ET, with DraftKings featuring multiple Millionaire Maker contests and FanDuel offering a contest with a $1 million total prize pool. GB/DET carries the highest total on the slate at 53.5, with the Lions favored by 3.5, and it is one of three games in the late window, with a 4:25 PM ET kickoff. SF/ATL is next at 49.5, with the 49ers favored by 2.5, followed by CIN/BAL at 49.0 (Ravens -1.5) and LAR/LV at 48.5 (Rams -3.5). CLE/TEN has the lowest total on the slate at 37.5. The Lions carry the highest implied team total at 28.5, with the Texans (26.5) and the 49ers and Rams (26.0) behind them, and Houston is the biggest favorite on the slate at 10.5 points over the Giants.

Injuries are shaping the slate again. Breece Hall (quad) is questionable after missing the last three games, and I'm writing this assuming he is out. Puka Nacua (calf) is questionable after missing Friday's practice, and I'm assuming he plays. Baker Mayfield (thumb) is listed as questionable but is expected to return after missing three games, and the Buccaneers have ruled out Emeka Egbuka (concussion/foot). Lamar Jackson (ankle) is questionable after missing the last two games, with Tyler Huntley starting both, and David Montgomery (groin) missed Week 6 for Houston and did not practice Wednesday or Thursday. Josh Jacobs was removed from the Commissioner's Exempt List on Monday and returned to practice this week, and he would join a Packers offense that has run for the fewest yards in the league.

Let's break down the positions, spotlight some of the best DFS options, and map out a path to the top of the leaderboards this Sunday.