Squirrel Patrol's Week 3 NFL Main Slate DFS GPP Picks

Sep 25, 2026

USA TODAY Network via Reuters Connect

Week 3 brings a 13-game main slate on Sunday, kicking off at 1 p.m. ET, and both sites are again featuring Millionaire Maker contests, with one on FanDuel and multiple on DraftKings. Two games carry totals above 50 points: BAL/DAL at 53.5, with the Ravens favored by 3.5 in the Rio de Janeiro game, and LAC/BUF at 50.5, with the Bills favored by 7.0. NYJ/DET and ARI/SF follow at 48.5, TEN/NYG has the lowest total on the slate at 38.5, and the Bills carry the highest implied team total at 28.75, with the Ravens and 49ers (28.5), Chiefs (28.0), and Lions (27.5) right behind them.

ARI/SF and MIN/TB kick off at 4:05 p.m. ET, with LV/NO and BAL/DAL at 4:25, which matters for late swap, and I'll come back to that at quarterback. As always, the picks below lean on our 4for4 projections and ownership first, with two weeks of usage as a supporting piece.

The Friday injury report is shaping the slate. Jayden Daniels (elbow) is out, so Marcus Mariota starts for Washington; Jaxson Dart is done for the season after knee surgery, which leaves Jameis Winston for the Giants; Nico Collins (hamstring) has been ruled out again; and Rico Dowdle (toe) is out for Pittsburgh, which hands the backfield to Jaylen Warren, who is questionable himself with a shoulder issue after three limited practices. Zay Flowers (hamstring) was limited on Friday and is questionable for Rio, and I'm writing this assuming he plays. Kyler Murray starts for Minnesota, Aaron Jones was cleared to play in Tampa, Sam Darnold is back for Seattle, and Brock Bowers is questionable but expected to make his season debut in New Orleans. D.J. Moore (shoulder) and Jalen Coker (ankle) are both questionable after missing practice late in the week; I'm assuming both play, and the 49ers had not released Mike Evans' (hip) status when this was written.