Mark Ingram, Brandin Cooks not practicing Friday

Chiefs WR Hollywood Brown is not expected to play during the regular season due to his shoulder injury.

Brown needs surgery on his shoulder. He was already placed on injured reserve and now his season ends before even taking a regular season snap with the Chiefs. This should means plenty of deep targets for rookie Xavier Worthy, as well as work in the run game, as we saw against the Ravens. Rashee Rice will gobble up targets as the main weapon for Patrick Mahomes. Unfortunate news for Hollywood.

Eagles WR A.J. Brown did not practice Saturday due to a hamstring injury and is listed as questionable for Monday’s game against the Falcons.

Brown began feeling tightness in his hamstring during practice Friday and Eagles head coach Nick Sirianni said the team would be “cautious” with him Saturday. So this could be a case of the Eagles just giving him some rest before Monday’s game. If Brown can’t go, Jahan Dotson could be in line for a bigger role Monday. If possible, have a backup option ready for Brown, such as Dotson if he’s available.

The 49ers are placing RB Christian McCaffrey (calf/Achilles) on injured reserve, per Adam Schefter of ESPN.

The 49ers had been leaning in this direction. They will now be without CMC for at least the next four weeks, meaning he will miss games against the Vikings, Rams, Patriots and Cardinals. He'll probably also miss a fifth game, as the 49ers have a short week after the Cardinals game before a Thursday night game in Week 6 against the Seahawks. Perhaps he can return for the Super Bowl LVIII rematch in Week 7 against the Chiefs. For now, it will be the Jordan Mason Show after his huge Week 1 performance against the Jets -- 28 carries, 147 yards.