Frank Gore, Michael Crabtree active for 49ers

Chargers HC Jim Harbaugh says RB Kimani Vidal will be "next man up".

Also says Hortiz will be scouring the market to see what is available at the position.

Related players: Omarion Hampton, Najee Harris, Hassan Haskins

With Harris lost for the season and Hampton expected to see a larger role ahead of Haskins, it means Vidal is just another injury away from possibly seeing significant snaps.

Ahead of Sunday's game against the Baltimore Ravens (4:25 p.m. ET, CBS), the Chiefs are optimistic Xavier Worthy will be able to play a limited role for the offense while wearing a small harness. Patrick Mahomes and HC Andy Reid say they are confident the Chiefs can continue to be successful on deep passes with Tyquan Thornton running routes alongside Worthy. By Week 7, Mahomes' dropbacks could feature him having a combination of quality options -- such as Travis Kelce, Thornton, Worthy, Rashee Rice and Hollywood Brown.

Slowly the Chiefs offense is starting to get healthy and back to what everyone envisioned at the start of the season. Worthy has a chance to play in Week 4 but the team is already saying he'll be limited, so fantasy owners will want to monitor just how much Worthy will play or maybe in what situations.

After an ugly start to the season, Titans head coach Brian Callahan has fired himself as the offensive play caller in Tennessee.

The team announced today that quarterbacks coach Bo Hardegree will call plays.

Titans offensive coordinator Nick Holz will remain in place, an unusual arrangement in which a team has an offensive coordinator but another assistant gets the play calling responsibility, the story points out. Callahan went 3-14 last season and so the leash may be getting shorter for him and his staff.