According to Ian Rapoport of NFL.com, "Carson Wentz, dealing with a back issue, is not expected to play this week, sources say. Depending on the result, given the time of year, Wentz may not play again in 2018. The team is still gathering info on his health."
The timing couldn't be worse for fantasy owners. With Nick Foles a poor option, you could look to Lamar Jackson, Josh Allen or even Derek Carr as options. Give our Streaming Quarterbacks and Waiver Wire Watch articles a read for other potential options that may be available in your league.
As far as the Eagles receivers go, aside from Zach Ertz, nobody has been particularly compelling of late anyway, so this doesn't change much on that front. Golden Tate and Alshon Jeffery remain in the low-end WR2/WR3 discussion and Ertz, who saw 23 targets and averaged 15.1 PPR points with Foles as the starter the first two weeks of the season, stays as a top option at tight end.
From John Paulsen: "Foles’s productivity has been all over the place in eight starts since 2017, including the playoffs. He was obviously great in last year’s postseason, but in two starts this year, he had a bad game against Atlanta (117 passing yards, one interception) before a pretty productive game against the Buccaneers (334 yards and a touchdown). In the seven starts since 2017 where he attempted at least 30 passes, he averaged 260 yards and 1.71 touchdowns against just 0.43 interceptions, but owners are warned against expecting too much in a tough spot against a surging Rams defense. The magic seems to be gone from this offense, though the Eagles may be forced to throw the ball a ton if/when they fall behind early against the Rams."