Colts vice chairman Bill Polian all but conceded that Peyton Manning would miss the opener in comments Monday to WISH-TV.
"He is going to be back at some point," Polian said. "What we don't know right now is what the results of the diagnostic tests are, what is the prognosis going forward. This is uncharted territory, but we do know that the nerve regeneration takes time and it just hasn't healed yet. It will.