Squirrel Patrol's Week 5 NFL Main Slate DFS GPP Picks

Oct 09, 2026

USA TODAY Network via Reuters Connect

Week 5 brings an 11-game main slate on Sunday, kicking off at 1 p.m. ET, and both sites are again featuring Millionaire Maker contests. DET/ARI carries the highest total on the slate at 54.5, with the Lions favored by 5.5, which is nine points higher than any other game. CHI/GB, LV/NE, and SF/SEA are next at 45.5, with the Bears favored by 1.5, the Patriots by 3.5, and the Seahawks by 3.0. HOU/TEN has the lowest total on the slate at 38.5, and the Lions carry the highest implied team total at 30.0, with the Bengals (25.25), the Cardinals and Patriots (24.5), and the Seahawks (24.25) behind them.

Injuries are shaping the slate again. The Jets have ruled out Breece Hall (quad) and Adonai Mitchell (finger), and the Bears have ruled out Kyle Monangai (toe). Chicago lists Caleb Williams (hamstring) as questionable after he missed the last two games, with Tyson Bagent in line to play again if Williams sits. Jayden Daniels (elbow) returns for Washington after missing two games. The Bengals list both Ja'Marr Chase (concussion) and Tee Higgins (groin) as questionable. Justin Jefferson (ankle) is questionable for the Vikings after missing last week, and I'm writing this assuming he plays.

Let's break down the positions, spotlight some of the best DFS options, and map out a path to the top of the leaderboards this Sunday.