Squirrel Patrol’s Week 6 NFL MNF Classic Slate DFS GPP Picks

Oct 13, 2025

Gregory Fisher-Imagn Images

Week 6 brings another Monday Night Football doubleheader, our third of the season already. The Bills (-4.5) visit the Falcons in Atlanta to kick things off at 7:15 PM ET, while the Bears head to Washington to face the Commanders (-5.5) an hour later at 8:15 PM ET. Both games carry a total of 49.5.

These slates are a personal favorite of mine because they combine Showdown strategy with a classic multi-game format, making for a long, entertaining night of NFL action. I also won my only solo Milly Maker on one of these slates in Week 2 of 2023, which helps to build my personal attachment to this format.

A couple of injury notes to monitor: Deebo Samuel and Chris Rodriguez (Commanders), Dalton Kincaid (Bills), and Colston Loveland (Bears) are all listed as Questionable. I’m assuming all are in for now, but keep your eye on the inactives (usually an hour and a half or so before each kickoff) if we don’t get confirmation beforehand.

The strategy for these two-game slates is just as important as the picks, so I’ll highlight some of the main points here:

While the number of teams in this format is limited, the number of positions isn’t. With a full nine roster spots to choose from, differentiation isn’t hard. One low-owned player is usually enough—I rarely dig deeper than a third wideout or a primary backup running back.
I typically stack my quarterback with more teammates than I would on a full main slate. With just two games, there’s a decent chance one turns into a dud, so I want as much exposure as possible to the higher-scoring matchup.
While I want to over-stack my lineups, be cautious on FanDuel, where we are limited to four players from the same team. If you set a rule to pair your QB with at least two WR/TE pass-catchers, you can’t also roster both that team’s RB and D/ST (since that would total five players from that team).
On a two-game slate, it’s perfectly fine to roster offensive players against the opposing defense. A special teams score can swing everything, and gives the ball right back to your offense.
Unlike the Week 2 MNF doubleheader, there is only an hour between the start times for these games, so late swap may not be a big factor. Still, if your lineup missed on a player who has a huge score early in the Bills – Bears game, consider a switch to more off-the-board players in the late game. Conversely, if your contrarian player hit for a big score early in the first game, you have some leeway to play things chalkier in the late game.

Let’s break down the positions, spotlight some of the best DFS options, and map out a path to the top of the leaderboards.