Squirrel’s Nuts & Bolts: Chargers vs Chiefs Showdown Strategy (Week 1 NFL DFS)

Sep 05, 2025
Squirrel’s Nuts & Bolts: Chargers vs Chiefs Showdown Strategy (Week 1 NFL DFS)

The NFL serves up its second appetizer of single-game contests this week, with the Chiefs and Chargers squaring off in our first international game of the season, live from São Paulo, Brazil, on Friday night. Kansas City enters as a 3-point favorite in this neutral-site matchup, with the total set at 46.5 points.

The Chiefs bring back most of the offense that reached last year’s championship game, though Rashee Rice is out due to suspension—opening opportunities for the remaining passing-game options. The Chargers made changes at running back, adding Najee Harris and Omarion Hampton to replace J.K. Dobbins. Harris missed time this preseason with a fireworks-related eye injury, but he’s expected to play, leaving some uncertainty (and opportunity for our DFS lineups) at the position.

Both teams were middle-of-the-pack in scoring offense last season, but elite on defense—the Chargers allowed the fewest points in the league, while the Chiefs allowed the fourth-fewest. For DFS single-game contests, that balance makes targeting efficient, high-upside plays critical. Let’s break down this AFC West showdown, spotlight the key plays, and uncover the strategies that could help you climb the leaderboards.

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