On top of James Conner likely missing this week and likely the next, the Cardinals are also expected to be playing without backup running back Darrel Williams due to a knee injury. Plus, they’ve placed running back Jonathan Ward on injured reserve with a hamstring injury.

Related Players: Eno Benjamin, Keaontay Ingram

The Seahawks' defense has allowed the most yards and second-most touchdowns on the ground while allowing the fifth-highest yards per attempt. Eno Benjamin looks to be operating in the workhorse role while Conner nurses up, which makes him an RB2 play in fantasy this weekend.

The Arizona Cardinals held a walk-through Wednesday as the first practice of the game week and released their injury report in preparation for the Seattle Seahawks.

The notable names that sat out of the walk-through included running backs James Conner and Darrel Williams, center Rodney Hudson and kicker Matt Prater.

Related players: Eno Benjamin

The Cards are hurting at running back coming into Week 6 and there's a chance Benjamin may be the last man standing. Now is the time to check waiver wires and pick him up.

On the Cardinals RB situation: James Conner is dealing with a rib issue, status will be clearer later in the week.

Related players: Darrel Williams, Eno Benjamin, Jonathan Ward, Corey Clement, Ty'Son Williams

The tweet went on to say Williams sprained his knee and is out this week and Ward is dealing with a hamstring injury and is on IR, per Tom Pelissero. The team recently signed Clement and Williams to the practice squad. One name not mentioned in terms of injuries is Benjamin, so if Conner is unable to go in Week 6, Benjamin would likely get a huge workload. Against the Eagles, Benjamin had eight carries and scored a TD while adding three catches. He's worth picking up if he's on your wire.

Kingsbury said Hollywood Brown just had a rest day. That was the case for most guys sitting.

James Conner day to day still.

Related players: Eno Benjamin, Darrel Williams

Conner is dealing with an ankle injury. In Week 1, Benjamin was the team's RB2 but in Week 2 Williams and Benjamin essentially split the workload, each getting 8 carries. It was Williams, however, who recorded 59 yards and also scored a TD. Conner looks on track to play in Week 3 but the situation is worth monitoring.

It's Eno Benjamin *or* Darrel Williams taking over No. 2 RB duties behind James Conner.

Related players: James Conner

Some who follow the team have said Williams didn't really stand out in camp and win the job as the RB2. Benjamin was expected to take the next step entering his second season, so it's just confusing for fantasy owners as far as what exactly the situation is for their Conner handcuff. It's perhaps more of a reflection that neither back stood out. For what it's worth, we're listing Benjamin as the team's RB2.

Arizona Cardinals running back Eno Benjamin has had an impressive offseason and is considered the favorite for number two duties behind starter James Conner.

Benjamin was a trendy breakout pick prior to NFL free agency and the 2022 NFL Draft, but the additions of Darrell Williams and Keontay Ingram all but evaporated the high hopes many had for the former Arizona State Sun Devil. Now, just days away from the first preseason game, it has become clear that Benjamin has improved enough in the passing game (particularly in pass protection) that he has the leg up in the battle to be James Conner's 'tag-teammate'. Benjamin could carve out flex value if he distances himself from Williams and Ingram during the preseason. More of a deep league target, Eno is currently our 79th-ranked running back.

The Arizona Cardinals have re-signed RB James Conner to a three-year contract.

With Chase Edmonds in Miami, Conner is the lead back unless the Cardinals spend a higher draft pick on a back in the 2022 NFL Draft.

Cardinals RB James Conner (heel) and WR Rondale Moore (hamstring) are active for Super Wild Card Monday against the Los Angeles Rams.

Conner active means Chase Edmonds should be no worse than in a 50/50 split, but loses his lead dog role. Moore has been used sporadically and is a true boom/bust play against the Rams.

Cardinals RB James Conner (heel) did not practice Friday, while RB Chase Edmonds (ribs/toe) and WR Rondale Moore (ankle) were limited.

A second DNP is bad news for Conner, especially with Edmonds ailing as well.