Barring a stunning turn of events, Anthony Castonzo will make his first start of the season and Marlon Mack will make his second.
A preseason darling here at 4for4, Mack is finally healthy. Currently ranked a conservative 43rd for the week at running back, today's news may push him up the board slightly into RB3 territory. Even then he isn't somebody you should be overly enthusiastic to start until we see how the Colts plan to split his worth with pass-catching specialist Nyheim Hines. Do make sure Mack is owned, as he should be rostered in all but the shallowest of leagues.