Who Should You Draft with the 12th Pick in 2025?

Aug 19, 2025

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Having the last pick in your draft is one of the most underrated strategic advantages in fantasy. Since you select two players at every go-around, you have lots of control over the specific roster archetype you want to build. In this article, I will be breaking down who you should draft with the 12th pick of a 12 team league, and also suggest the best players to complement that choice with the 2.01. All ADP info comes from our multi-site ADP tool.

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WR Nico Collins, Texans (ADP: 12th overall)

Nico Collins is coming off consecutive phenomenal fantasy seasons, finishing as the WR6 in PPG in 2023 and the WR7 in 2024. He has performed this well despite actually being held back a bit by the Texans offense. Last year, under offensive coordinator Bobby Slowik, the Texans continuously shot themselves in the foot on 1st and 2nd down by running the ball. Their early down success rate (percentage of plays with EPA > 0) ranked 31st in the NFL, and C.J. Stroud ranked 2nd in the NFL in 3rd-and-long dropbacks. Collins also faced respectable target competition from Tank Dell and Stefon Diggs last year. As a result of this situation, along with an injury that kept him out five weeks, Collins’ final stat line was hindered a bit, but his advanced numbers and film grades were both phenomenal: Collins ranked 3rd among receivers in yards per route run and targets per route run, and 2nd in PFF receiving grade.

With Sean McVay disciple Nick Caley replacing Slowik as the Texans OC, Diggs no longer in town, and Dell expected to miss much of the year due to a leg injury, Collins has legendary upside this season. He should command nearly all of the volume in a Texans offense that should be way more pass-heavy in 2025, giving him overall WR1 potential.

RB Derrick Henry, Ravens (ADP: 13th overall)

Derrick Henry continued to fight off Father Time last season in Baltimore, running for nearly 2,000 yards and totaling 18 touchdowns en route to an RB3 finish. While he might be due for some regression in those categories, it’s hard to imagine his production falling off too much, given the powerhouse that is the Ravens rushing attack. It’s telling that Henry’s yards-per-carry mark was nearly 6.0 last season next to Lamar Jackson, after being below 4.5 in each of his last three years in Tennessee. Henry may not have the same lofty upside as Bijan Robinson or Jahmyr Gibbs due to his lack of pass-catching value, but every other box of his is checked. He has run for 10+ touchdowns in seven straight seasons and has shown no signs of slowing down at age 31, making him as close to a sure thing as possible in fantasy in non-full-PPR formats.

RB De'Von Achane, Dolphins (ADP: 14th overall)

The vibes coming out of Dolphins training camp have been pretty miserable, and I’ve soured on De'Von Achane in the last few weeks. He reportedly suffered a calf injury in camp and will be held out of practice for a week. Soft-tissue injuries are always a concern for running backs, especially for someone like Achane, who relies on his speed and explosiveness to produce. Achane was excellent in fantasy last season when quarterback Tua Tagovailoa was healthy, averaging 19.5 fantasy points per game in Tagovailoa’s 11 starts. However, it feels like betting on Achane this year is a bet on both him and Tagovailoa to stay healthy, which is a risky endeavor at the 1/2 turn. Achane certainly does have a high ceiling because of his rushing efficiency and receiving work, but know that it comes with serious downside.

WR Brian Thomas Jr., Jaguars (ADP: 15th overall)

Considering the surrounding context of the Jaguars offense, Brian Thomas Jr. probably doesn’t get enough credit for what he did his rookie year. He posted 1,282 yards and 10 touchdowns on 87 catches, finishing the year as the overall WR4 (WR12 in PPG) despite catching passes from Mac Jones for eight weeks. Now that offensive wizard Liam Coen is in town as the Jaguars head coach and quarterback Trevor Lawrence is fully healthy, I think the Jags have a real chance to win the AFC South powered by their offense. While Travis Hunter may challenge Thomas for targets, Hunter’s offense/defense snap split is unknown and he may not be a full-time receiver. Even if he is, Thomas will still be the clear No. 1 receiver for this team, and could push for 100+ catches in his second year — after earning a permanent role in the offense in Week 9 last year, Thomas’ 17-game pace was 103 catches for 1339 yards and 13 scores. Like Collins, he has overall WR1 potential if he can keep his red zone scoring production up, and offers a high floor even if he regresses in the touchdown department.

Who Should You Draft?

All four of these players have legitimate cases to be taken at the 1/2 turn. Here is the pair of players I would select based on scoring format:

In full-PPR formats, I like the idea of doubling down on elite receivers who could both finish as the overall WR1. You could then take two solid running backs like Kenneth Walker and Omarion Hampton at the 3/4 turn. In half-PPR and standard formats, Henry’s reliability is too strong to overlook, and I would target a more balanced build with Henry as my RB1. I am avoiding Achane in this range of drafts and wouldn’t be surprised if his ADP starts to drop in the coming weeks.