According to Staley, wide receiver Mike Williams, safety Nasir Adderley and cornerback Chris Harris Jr. will miss the pivotal game due to being on the reserve/COVID-19 list, per Fernando Ramirez of SI.
Williams was added to the list on Christmas, and due to the 10-day quarantine rule for unvaccinated players, he will miss Sunday. The NFL recently updated their protocols so that vaccinated players could "test out" of protocols more quickly. Since Adderley and Harris have already been ruled out, it would appear they are unvaccinated as well, according to the story. It's possible Guyton could test out and return. Moore caught three passes for 56 yards in Week 16.
LAC WR Jalen Guyton - Week 14 Fantasy Football Outlook
Week 14 vs. Giants
Jalen Guyton looks set for an increased workload in Week 14 with both Keenan Allen and Mike Williams likely to be sitting out against the Giants. Guyton comes into the game in some form, having caught all four of his targets for 90 yards and a touchdown last week. Guyton has just 18 receptions for 289 yards and a single score in 2021.
The Giants ranked 14th in aFPA allowed to wide receivers, and given their weaknesses towards opposition running backs it's not likely that Guyton will make too much noise from a fantasy standpoint. He's a low-end WR3 option at best.