Pittman had a fantasic start to the season, catching nine passes (on 13 targets) for 121 yards and a touchdown and was set for another strong matchup against the Jaguars. But a quad injury suffered Wednesday caused him to miss practice Thursday and Friday. The Colts were holding out hope he would play Sunday, but they are going to play it safe with their top receiver. The Colts will also be without Alec Pierce. Their current receivers are Parris Campbell, Ashton Dulin, Mike Strachan, Dezmon Patman and Keke Coutee, whom the Colts just elevated from the practice squad. This hurts the value of Matt Ryan, who now sits as QB22 in this week's rankings. Jonathan Taylor remains our RB1 for the week and he could see a heavy workload Sunday.