Big Deal for Peyton Manning

San Francisco 49ers running back Isaac Guerendo plans to play Thursday night against the Los Angeles Rams despite his sprained foot, sources told ESPN's Adam Schefter.

Guerendo, who is listed as questionable, insists he "feels good," sources said.

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We're projecting Patrick Taylor as the next man up in the 49ers' version of running back roulette *if* Guerendo is forced out, as he easily has the most familiarity with the team. Abanikanda can be stashed if that's not the case, but shouldn't be in starting consideration if Guerendo does indeed miss Week 15.

Otherwise, consider the fourth-round rookie a fantasy RB2.

— The 49ers ruled out LT Trent Williams (ankle) and S Malik Mustapha (chest), but RB Isaac Guerendo (foot) is questionable. So is Dre Greenlaw, who was full today.
— The Rams ruled out TE Tyler Higbee (knee) and Cobie Durant (chest).

Related Players: Patrick Taylor, Israel Abanikanda, Kyle Juszczyk, Ke'Shawn Vaughn

We're projecting Patrick Taylor as the next man up in the 49ers' version of running back roulette, as he easily has the most familiarity with the team. Abanikanda can be stashed if that's not the case, but shouldn't be in starting consideration if Guerendo does indeed miss Week 15.

Rams are listing WR Demarcus Robinson (shoulder), WR Jordan Whittington (shoulder), and TE Davis Allen (shoulder) as questionable for Thursday night’s game versus the 49ers.

Related Players: Puka Nacua, Cooper Kupp, Tutu Atwell, Tyler Johnson

This doesn't really impact Nacua or Kupp either way, but Atwell could log a little extra work here. Consider him a very deep league WR5.