Goodwin sat out practice for the second straight day Thursday. On Wednesday, coach Kyle Shanahan told reporters he wasn't sure if Goodwin would be able to play Sunday or not.
Goodwin has consistently been in the WR2/3 conversation in our rankings. Him missing a game will be a blow to owners, but the waiver wire is rife with options this week. Check out our Sneaky Starts and Waiver Wire Watch articles if you are in need of a fill-in.