Squirrel Patrol’s Week 6 NFL Main Slate DFS GPP Picks

Oct 10, 2025
Squirrel Patrol’s Week 6 NFL Main Slate DFS GPP Picks

Week 6 brings a 10-game main slate on Sunday, with another international game Sunday morning, two Monday Night games, and two teams on a bye. Both FanDuel and DraftKings have posted huge prize pools, including two Millionaire Maker tournaments on DraftKings.

Game totals continue to be tightly bunched, with eight of the ten matchups on the slate sitting between 44.5 and 49.5 points. The only outliers on the game totals are to the under, with the CLE/PIT matchup at 37.5 and the TEN/LV game at 41.5. We see some large spreads, with Green Bay (-14.5) favored by more than two touchdowns, while the Colts (-7) and Rams (-7) are both favored by a touchdown. Injuries, particularly at running back, continue to shape the DFS landscape, and we have a number of big names like Zay Flowers, Kyler Murray, and Alvin Kamara listed as Questionable.

Let’s break down the positions, spotlight some of the best DFS options, and map out a path to the top of the leaderboards this Sunday.

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