49ers Inactives

Michael Penix Jr. carries no injury designation for Sunday’s game against Chicago and will start. Penix injured his ribs during Atlanta’s Week 5 loss to Baltimore but avoided a setback during the practice week.

Related Players: Drake London, Jahan Dotson, Zachariah Branch, Olamide Zaccheaus, Chris Blair, Kyle Pitts, Austin Hooper, Bijan Robinson, Brian Robinson

Penix is a solid superflex QB2 and a streaming option for managers replacing an injured starter. London remains a strong WR1, and Bijan Robinson is an automatic start. Pitts is still a touchdown-dependent TE2; Penix’s availability alone does not make Atlanta’s secondary pass catchers reliable options in standard-sized leagues. Tagovailoa can stay on waivers outside leagues that roster backup quarterbacks.

The Buccaneers will release their final injury report of the week later on Friday afternoon, but immediately following practice Head Coach Todd Bowles revealed that quarterback Baker Mayfield and safety Antoine Winfield Jr. have been ruled out of Sunday's game against the Pittsburgh Steelers.

Related Players: Jalon Daniels, Emeka Egbuka, Chris Godwin, Ted Hurst, Tez Johnson, Kameron Johnson, Cade Otton, Bucky Irving, Kenneth Gainwell, Sean Tucker

Daniels’ rushing ability makes him a usable superflex QB2 and an emergency streaming option in one-quarterback leagues. Egbuka remains a WR3/FLEX play, while Godwin is a more volatile PPR FLEX. Otton belongs in the TE2 streaming pool rather than starting lineups by default. Irving remains a viable RB2, but Mayfield’s absence lowers the offense’s passing and scoring ceiling.

Ravens QB Lamar Jackson is not present during media viewing portion of Friday’s practice, which indicates Tyler Huntley will likely start for the second straight week.

Jackson missed every practice this week and hasn’t suited up since spraining his left ankle in a win over the Titans on Oct. 4.

Huntley has won his last three starts as a fill-in starter for Jackson. In those three victories with Huntley, Baltimore has averaged 33.7 points.

Related Players: Zay Flowers, Rashod Bateman, Ja'Kobi Lane, Devontez Walker, Elijah Sarratt, LaJohntay Wester, Mark Andrews, Matthew Hibner, Josh Cuevas, Derrick Henry, Justice Hill

Jackson’s managers should prepare to use another quarterback. Huntley would be a viable superflex QB2 if he starts, with rushing production providing part of his appeal. Flowers remains a WR2 if cleared from his toe injury, while Andrews would be a touchdown-dependent streamer. Henry remains an RB1 regardless of the quarterback decision.