It's hard to blame the Bills from straying away from RB C.J. Spiller (12-of-69 snaps). Spiller was stopped for a 3-yard loss on the first play of the game, an avoidable play where Spiller ran away from the line of scrimmage at one point trying to elude a defender.
Spiller ran only twice after his late first-half fumble, although part of that was the scoreboard; the Bills were trailing more as the game progressed.
The team chose to put the ball in the hands of Fred Jackson who came in with an ankle injury. Jackson played on 52-of-69 snaps and recorded a TD. Spiller's workload continues to dwindle and he's becoming less and less of a usable fantasy option.