Squirrel Patrol’s Week 10 NFL Main Slate DFS GPP Picks
Week 10 brings a 10-game main slate on Sunday, featuring a morning kickoff in Berlin and four teams on bye. Both FanDuel and DraftKings continue to roll out massive prize pools, with DraftKings once again offering two Millionaire Maker tournaments.
The recent trade deadline highlighted the diverging paths of NFL teams – some bolstered their rosters for a playoff push, while others effectively waved the white flag by trading away key pieces. That’s reflected in this week’s lines: we see both lopsided spreads and some notably low totals in games between non-contenders.
Five of the ten games feature totals of 48 points or higher — BUF/MIA (BUF -9.5, 50.5), BAL/MIN (BAL -3.5, 48.5), NE/TB (TB -2.5, 48.5), DET/WAS (DET -8.5, 49.5), and LA/SF (LA -5.5, 49.5). Injuries also remain a factor, with Rhamondre Stevenson, Brian Thomas Jr., Ricky Pearsall, and Bucky Irving all ruled out.
Let’s break down the positions, spotlight some of the best DFS options, and map out a path to the top of the leaderboards this Sunday.
Quarterbacks
- DFS & Season-Long Content
- Lineup Generator
- Optimal Cash & GPP Lineups
- Floor & Ceiling Projections
- -Leverage Scores
- -...and much much more!

















