It's a big blow to the offense and especially the special teams where Agnew originally made his mark this season. But as of late, Agnew was getting more reps as a WR2. The Jags offense, especially the passing game, is one to mostly stay away from in terms of fantasy production.
It's a huge loss for the Jags and QB Trevor Lawrence. Jones looks like he'll be the WR1 going forward. Shenault has had mixed results with Chark out of the lineup so far. Agnew and Austin will look to battle for WR3 snaps, which could have significance as the Jags are expected to play from behind a lot the rest of the season.