49ers running back Matt Breida left the first preseason game with a shoulder injury and did not return.
Fantasy Impact:
This would be a fairly significant injury, fantasy-wise, as Breida is expected to be closer to a 1B than a true No. 2 back to Jerick McKinnon this year. If he misses any time, it could leave McKinnon in a true workhorse role, or open up some touches for 2017 draft pick Joe Williams.