Jason La Canfora: To the surprise of no one, Colts make it official no Andrew Luck in Week 1. Scott Tolzien gets the start. I'd expect Luck to miss a few more weeks.
From ESPN Stats & Info: Scott Tolzien is 0-2-1 w/a 27.8 Total QBR in his career as a starting quarterback. Since 2013, it's the third-worst QBR in a player’s first three career starts.
Interesting note there at the end from La Canfora, who suggests that Luck will "miss a few more weeks." While he's out, T.Y. Hilton, Donte Moncrief and Jack Doyle will all suffer, and Frank Gore is less dependable in the running game.